P
Ping Wen
Researcher at Nanjing Medical University
Publications - 25
Citations - 1342
Ping Wen is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Renal fibrosis & Kidney. The author has an hindex of 15, co-authored 23 publications receiving 1062 citations.
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The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression
TL;DR: The results suggest that downregulation of the miR-200 family initiates the dedifferentiation of renal tubules and progression of renal fibrosis, which might provide important targets for novel therapeutic strategies.
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Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury
TL;DR: The data suggested that autophagy might be interrupted due to the failure of ER cytoprotective capacity upon high glucose induced unmitigated stress, and the defective autophile might accelerate the irreparable progression of diabetic nephropathy.
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WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression.
TL;DR: It is suggested that high-phosphate may activate WNT/β-catenin signaling through different pathways, and the activated WNT-3A/ β-catanin signaling, through direct downstream target Runx2, could play an important role in promoting VOT and AMC.
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Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway
TL;DR: It is suggested that uric acid induces renal inflammation via activation of NF-κB signaling through infiltration of T cells and macrophages in hyperuricemia mice kidneys.
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Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathy
Xiaohua Wang,Yang Zhou,Ruoyun Tan,Mingxia Xiong,Weichun He,Li Fang,Ping Wen,Lei Jiang,Junwei Yang +8 more
TL;DR: It is demonstrated that ablation of MMP-9 attenuated renal interstitial fibrotic lesions in obstructive nephropathy and established a crucial and definite importance of M MP-9 in the pathogenesis of renal Interstitial fibrosis at the whole-animal level.