WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression.
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TLDR
It is suggested that high-phosphate may activate WNT/β-catenin signaling through different pathways, and the activated WNT-3A/ β-catanin signaling, through direct downstream target Runx2, could play an important role in promoting VOT and AMC.About:
This article is published in Experimental Cell Research.The article was published on 2016-07-15 and is currently open access. It has received 159 citations till now. The article focuses on the topics: Wnt signaling pathway & DKK1.read more
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Journal ArticleDOI
WNT Signaling in Cardiac and Vascular Disease
Sébastien Foulquier,Evangelos P. Daskalopoulos,Gentian Lluri,Kevin C.M. Hermans,Arjun Deb,W. Matthijs Blankesteijn +5 more
TL;DR: A general picture is emerging that excessive stimulation of WNT signaling adversely affects cardiovascular pathology, and a rapidly increasing collection of drugs interfering at different levels of W NT signaling will allow the evaluation of therapeutic interventions in the pathway in relevant animal models of cardiovascular diseases and eventually in patients in the near future.
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WNT–β-catenin signalling — a versatile player in kidney injury and repair
TL;DR: Advances in the understanding of WNT–β-catenin signalling and its regulation during kidney injury, along with its potential diagnostic and therapeutic implications are discussed.
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The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification.
TL;DR: A better understanding of this process could lead to new therapies to boost fracture healing and tackle bone-wasting disorders, as well as the possible signaling pathways that contribute to chondrocyte-to-osteoblast transdifferentiation processes.
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Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia.
Jakob Voelkl,Florian Lang,Kai-Uwe Eckardt,Kerstin Amann,Makoto Kuro-o,Andreas Pasch,Burkert Pieske,Ioana Alesutan +7 more
TL;DR: Critical intracellular pathways controlling osteo-/chondrogenic transdifferentiation of VSMCs are addressed and elucidating these pathways holds a significant promise to open novel therapeutic opportunities counteracting the progression of vascular calcification in CKD.
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Role of phosphate sensing in bone and mineral metabolism
Sampada Chande,Clemens Bergwitz +1 more
TL;DR: The metabolic effects of Pi are discussed, which are mediated by Pi transporters, inositol pyrophosphates and SYG1–Pho81–XPR1 (SPX)-domain proteins to maintain cellular phosphate homeostasis in the musculoskeletal system.
References
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Journal ArticleDOI
The many faces and functions of β‐catenin
TL;DR: One focus will be the interaction of β‐catenin with different transcription factors and the potential implications of these interactions for direct cross‐talk between β‐ catenin and non‐Wnt signalling pathways.
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Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
TL;DR: It is shown by conditionally deleting beta-catenin in limb and head mesenchyme that beta- catenin is required for osteoblast lineage differentiation, preventing transdifferentiation of osteoblastic cells into chondrocytes.
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Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Tripti Gaur,Christopher J. Lengner,Hayk Hovhannisyan,Ramesh A. Bhat,Peter V.N. Bodine,Barry S. Komm,Amjad Javed,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +10 more
TL;DR: It is proposed that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-β signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.
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Proximal events in Wnt signal transduction
Stephane Angers,Randall T. Moon +1 more
TL;DR: Intriguingly, the transmembrane receptor Tyr kinases Ror2 and Ryk, as well as Frizzled receptors that act independently of LRP5 or LRP6, function as receptors for Wnt and activate β-catenin-independent pathways, which leads to changes in cell movement and polarity and to the antagonism of the β- catenin pathway.
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Vascular Calcification Pathobiology of a Multifaceted Disease
Linda L. Demer,Yin Tintut +1 more
TL;DR: Clinically, vascular calcification is now accepted as a valuable predictor of coronary heart disease, and, conversely, many treatments for cardiovascular disease such as statins, antioxidants, hormone replacement therapy, ACE inhibitors, fish oils, and calcium channel blockers may affect bone health.