P
Plato A. Magriotis
Researcher at University of Patras
Publications - 41
Citations - 1032
Plato A. Magriotis is an academic researcher from University of Patras. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 18, co-authored 41 publications receiving 1004 citations. Previous affiliations of Plato A. Magriotis include Merck & Co. & Harvard University.
Papers
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Journal ArticleDOI
Direct Catalytic Enantioselective Reduction of Achiral α,β-Ynones. Strong Remote Steric Effects Across the C−C Triple Bond
Journal ArticleDOI
Recent Progress in the Enantioselective Synthesis of β-Lactams: Development of the First Catalytic Approaches
Journal ArticleDOI
A highly selective synthesis of versatile (E)-1-phenylthio vinylstannanes
TL;DR: In this article, an efficient, palladium-catalyzed hydrostannation of 1-phenylthio-1alkynes was described, and a tributyltin hydride addition was added to provide versatile 1-PNYLthio vinylstannanes regio-and stereoselectively.
Patent
Substituted beta-alanine derivatives as cell adhesion inhibitors
Philippe L. Durette,William K. Hagmann,Ihor E. Kopka,Malcolm MacCoss,Sander G. Mills,Richard A. Mumford,Plato A. Magriotis +6 more
TL;DR: The β-Alanine derivatives of formula (I) are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies as discussed by the authors.
Journal ArticleDOI
The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists
William K. Hagmann,Philippe L. Durette,Thomas J. Lanza,Nancy J. Kevin,Stephen E. de Laszlo,Ihor E. Kopka,David N. Young,Plato A. Magriotis,Bing Li,Linus S. Lin,Ginger X. Yang,Theodore M. Kamenecka,Linda L. Chang,Jonathan E. Wilson,Malcolm MacCoss,Sander G. Mills,Gail Van Riper,Ermengilda McCauley,Linda A. Egger,Usha Kidambi,Kathryn A. Lyons,Stella H. Vincent,Ralph A. Stearns,Adria Colletti,Johannes Teffera,Sharon Tong,Judy Fenyk-Melody,Karen Owens,Dorothy Levorse,Philip Kim,John A. Schmidt,Richard A. Mumford +31 more
TL;DR: SAR and pharmacokinetic characterization of this series of sulfonylated dipeptide inhibitors with structural components that when combined in a single hybrid molecule gave a sub-nanomolar inhibitor as a lead for medicinal chemistry are presented.