L
Linda A. Egger
Researcher at Merck & Co.
Publications - 20
Citations - 3114
Linda A. Egger is an academic researcher from Merck & Co.. The author has contributed to research in topics: Integrin & Beta (finance). The author has an hindex of 12, co-authored 18 publications receiving 2997 citations.
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Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal Article
IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor.
Julia M. Ayala,Ting-Ting Yamin,Linda A. Egger,Jayne Chin,Matthew J. Kostura,Douglas K. Miller +5 more
TL;DR: The inability to identify active ICE in stimulated monocytic cells was probably a reflection of the very low levels of active ICE present.
Journal ArticleDOI
Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.
Douglas K. Miller,Julia M. Ayala,Linda A. Egger,S.M. Raju,T.T. Yamin,Gloria J.-F. Ding,E.P. Gaffney,Andrew D. Howard,Oksana C. Palyha,Anna M. Rolando +9 more
TL;DR: Results indicate that the p10 protein is essential for ICE activity and that the ICE holoenzyme contains an intact p10 subunit paired with a p20 or p22 catalytic subunit.
Journal ArticleDOI
The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists
William K. Hagmann,Philippe L. Durette,Thomas J. Lanza,Nancy J. Kevin,Stephen E. de Laszlo,Ihor E. Kopka,David N. Young,Plato A. Magriotis,Bing Li,Linus S. Lin,Ginger X. Yang,Theodore M. Kamenecka,Linda L. Chang,Jonathan E. Wilson,Malcolm MacCoss,Sander G. Mills,Gail Van Riper,Ermengilda McCauley,Linda A. Egger,Usha Kidambi,Kathryn A. Lyons,Stella H. Vincent,Ralph A. Stearns,Adria Colletti,Johannes Teffera,Sharon Tong,Judy Fenyk-Melody,Karen Owens,Dorothy Levorse,Philip Kim,John A. Schmidt,Richard A. Mumford +31 more
TL;DR: SAR and pharmacokinetic characterization of this series of sulfonylated dipeptide inhibitors with structural components that when combined in a single hybrid molecule gave a sub-nanomolar inhibitor as a lead for medicinal chemistry are presented.
Journal ArticleDOI
Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4.
Linus S. Lin,Thomas J. Lanza,Laurie A. Castonguay,Theodore M. Kamenecka,Ermenegilda McCauley,Gail Van Riper,Linda A. Egger,Richard A. Mumford,Xinchun Tong,Malcolm MacCoss,John A. Schmidt,William K. Hagmann +11 more
TL;DR: A series of heterocyclic bioisosteres for an anilide based on molecular modeling found excellent potency was retained in the benzoxazole and the benzimidazole derivatives, where a hydrogen bond acceptor is appropriately positioned to mimic the amide bond oxygen.