P
Po H. Lu
Researcher at University of California, Los Angeles
Publications - 71
Citations - 5746
Po H. Lu is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: White matter & Dementia. The author has an hindex of 40, co-authored 64 publications receiving 5198 citations. Previous affiliations of Po H. Lu include Veterans Health Administration & West Los Angeles College.
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Journal ArticleDOI
Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study.
TL;DR: The changes in white matter suggest that the adult brain is in a constant state of change roughly defined as periods of maturation continuing into the fifth decade of life followed by degeneration.
Journal ArticleDOI
Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease.
George Bartzokis,George Bartzokis,David L. Sultzer,David L. Sultzer,Po H. Lu,Po H. Lu,Keith H. Nuechterlein,Jim Mintz,Jim Mintz,Jeffrey L. Cummings +9 more
TL;DR: MRI data suggest that the severity of age-related myelin breakdown is regionally heterogeneous, consistent with the hypothesis that differences in myelin properties make later-myelinating regions more susceptible to this process.
Journal ArticleDOI
Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.
George Bartzokis,George Bartzokis,Todd A. Tishler,Todd A. Tishler,Po H. Lu,Po H. Lu,Pablo Villablanca,Lori L. Altshuler,Lori L. Altshuler,Michele Carter,Danny Huang,Nancy Edwards,Nancy Edwards,Jim Mintz,Jim Mintz +14 more
TL;DR: This is the first demonstration of gender differences in brain ferritin iron levels and it is possible that brain iron accumulation is a risk factor that can be modified.
Journal ArticleDOI
Lifespan trajectory of myelin integrity and maximum motor speed
George Bartzokis,George Bartzokis,Po H. Lu,Kathleen Tingus,Mario F. Mendez,Mario F. Mendez,Aurore Richard,Douglas G. Peters,Bolanle Oluwadara,Katherine A. Barrall,J. Paul Finn,Pablo Villablanca,Paul M. Thompson,Jim Mintz +13 more
TL;DR: The results suggest that in this very healthy male sample, maximum motor speed requiring high-frequency AP burst may depend on brain myelin integrity, which may aid in developing and targeting anti-aging treatments to mitigate age-related functional declines.
Journal ArticleDOI
Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications.
George Bartzokis,Po H. Lu,Todd A. Tishler,Sophia M. Fong,Bolanle Oluwadara,Æ J. Paul Finn,Danny Huang,Yvette Bordelon,Jim Mintz,Susan Perlman +9 more
TL;DR: Early in the HD process, myelin breakdown and changes in ferritin iron distribution underlie the pattern of regional toxicity observed in HD, and tracking the effects of novel interventions that reduce myelinate later in development and are relatively spared in HD could hasten the development of preventive treatments.