Keith H. Nuechterlein

TL;DR: The MATRICS Consensus Cognitive Battery is expected to be the standard tool for assessing cognitive change in clinical trials of cognition-enhancing drugs for schizophrenia and may also aid evaluation of cognitive remediation strategies.

TL;DR: Empirical evidence for cognitive performance dimensions in schizophrenia was evaluated and seven separable cognitive factors were replicable across studies and represent fundamental dimensions of cognitive deficit in schizophrenia: Speed of Processing, Attention/Vigilance, Working Memory, Verbal Learning and Memory, Visual Learning and memory, Reasoning and Problem Solving, and Verbal Comprehension.

TL;DR: The evidence that certain deficits in information processing and attentional functioning are present across populations at risk for schizophrenic disorder, with active schizophrenic psychotic symptomatology, and in relative remission after a schizophrenic psychosis is examined.

TL;DR: A tentative model of schizophrenic psychotic episodes is presented, based on the evidence that certain characteristics of individuals may serve as vulnerability factors and that environmental stressors may precipitate psychotic periods in vulnerable individuals.

TL;DR: In the first MATRICS consensus conference as discussed by the authors, the goal was to identify the cognitive domains that should be represented in a consensus cognitive battery and prioritize key criteria for selection of tests for the battery.