Pradeep Kumar Sundaravadivelu

TL;DR: This biological recombinant Ets2 protein can substitute viral and genetic forms of ETS2 in a cell reprogramming process to facilitate the generation of clinical-grade cells and can also be used to investigate its molecular role in various biological processes and diseases.

TL;DR: A recent review as mentioned in this paper provides an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human induced Pluripotent Stem Cells (iPSCs) derived from healthy and diseased subjects.

TL;DR: In this article, the current state of iPSC generation, explicitly focusing on promising reprogramming strategies such as nonintegrating viral (Sendai virus vectors) and non-viral (episomal vectors, mRNAs, microRNas, recombinant proteins, and small molecules) approaches, providing an insight into the basic nuances used for the derivation of integration free iPSCs.

TL;DR: In this article, the authors identified optimal expression parameters to obtain soluble expression of human GATA4 in E coli and purified the same to homogeneity under native conditions using immobilized metal ion affinity chromatography.

TL;DR: This recombinant PDX1 fusion protein can be used as a safe tool and can potentially replace its genetic and viral forms in the reprogramming process to induce a β-cell-specific transcriptional profile in an integration-free manner.