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Showing papers by "Prakash Radhakrishnan published in 2015"

Journal Article•DOI•
Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

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Poomy Pandey1, Satyanarayana Rachagani1, Srustidhar Das1, Parthasarathy Seshacharyulu1, Yuri Sheinin1, Naava Naslavsky1, Zenggang Pan2, Brittney L. Smith1, Haley L. Peters3, Haley L. Peters1, Prakash Radhakrishnan, Nicole R. McKenna1, Nicole R. McKenna4, Sai Srinivas Panapakkam Giridharan5, Sai Srinivas Panapakkam Giridharan1, Dhanya Haridas1, Sukhwinder Kaur1, Michael A. Hollingsworth, Richard G. MacDonald, Jane L. Meza1, Steve Caplan, Surinder K. Batra, Joyce C. Solheim •
University of Nebraska Medical Center1, University of Colorado Denver2, University of Texas MD Anderson Cancer Center3, University of Virginia4, University of Michigan5
10 Feb 2015-Oncotarget
TL;DR: Stable knock-down of APLP2 expression (with inducible shRNA) in pancreatic cancer cells reduced the ability of these cells to migrate and invade and down-regulation ofAPLP2 decreased the weight and metastasis of orthotopically transplanted pancreatic tumors in nude mice.
Abstract: Amyloid precursor-like protein 2 (APLP2) is aberrantly expressed in pancreatic cancer. Here we showed that APLP2 is increased in pancreatic cancer metastases, particularly in metastatic lesions found in the diaphragm and intestine. Examination of matched human primary tumor-liver metastasis pairs showed that 38.1% of the patients had positive APLP2 expression in both the primary tumor and the corresponding liver metastasis. Stable knock-down of APLP2 expression (with inducible shRNA) in pancreatic cancer cells reduced the ability of these cells to migrate and invade. Loss of APLP2 decreased cortical actin and increased intracellular actin filaments in pancreatic cancer cells. Down-regulation of APLP2 decreased the weight and metastasis of orthotopically transplanted pancreatic tumors in nude mice.

24 citations