Pravin T. P. Kaumaya

TL;DR: This is the first report demonstrating that a nonstructural protein encoded by EBV is a pathogen-associated molecular pattern and that it has immunomodulatory functions and the dUTPase could be a potential target for the development of novel therapeutic agents against infections caused byEBV.

TL;DR: Two peptides which incorporate determinants of the fimbrial subunit co-linearly synthesized with a "promiscuous" T-cell epitope from the fusion protein of measles virus are synthesized.

TL;DR: This multiepitope vaccine in combination with IL-12 caused a significant reduction in the number of pulmonary metastases induced by challenge with syngeneic tumor cells overexpressing HER-2, and may have potential application in the treatment of Her-2-associated cancers.

TL;DR: Egged tow peptides to encompass the sequences from the universally immunogenic tetanus toxoid (TT) epitope and the contraceptive vaccine candidate lactate dehydrogenase C4 are engineered, demonstrating the feasibility of using ‘promiscuous’ T‐Cell epitopes colinearly constructed with a defined B‐cell epitope to induce high titer antipeptide IgG antibodies specific for native protein antigen LDH‐C4 in several inbred strains of mice, outbred

TL;DR: The data demonstrate that the antibody response to retroviral peptides is enhanced by promiscuous peptide constructs, in part because of the ability of such constructs to promote appropriate secondary structural forms of viral epitopes.