Showing papers by "Prem Chandra Pandey published in 2023"
TL;DR: In this article , the authors emphasized that achieving the SDG objectives is attainable through agriculture, which has direct and indirect connections to all the SDGs, including SDG 1 - No Poverty, SDG 2 - Zero Hunger, SDGs 3 - Good Health and Well-being, SDD 13 - Climate Action, and SDG 15 - Life on Land.
Abstract: Food security is a global challenge that aligns with several Sustainable Development Goals (SDGs), including SDG 1 - “No Poverty”, SDG 2 - “Zero Hunger,” SDG 3 - “Good Health and Well-being,” SDG 13 - “Climate Action,” and SDG 15 - “Life on Land.”. To effectively address this issue, a convergence of agriculture and technology is crucial, incorporating precision agriculture, sustainable agriculture, bio-economy and advanced technologies such as machineries, Artificial intelligence-meachine learning and geospatial technology. Recent trends in food security worldwide have witnessed the adoption of technological advancements. However, it is important to consider biodiversity when implementing and adopting technological advancements. The integration of technology in agricultural practices aim to reduce chemical usage in farms, while increased production remains the main objective of smart farming and Precision Agriculture. By minimizing the use or implementing localized approaches for chemicals on farms, we can preserve soil-faunal diversity, which is at risk along with targets due to excessive applications of pesticides, herbicides, and insecticides. Geospatial technology plays a significant role by leveraging remotely sensed images acquired through satellites, aerial platforms, and GPS-tagged drones to enhance agricultural practices, improve crop growth and increase crop yields. Through geospatial technology, we can map and monitor soil and crop conditions, and effectively conserve, protect, and manage biodiversity on a global scale. The applications of remote sensing technology consider ecological and environmental parameters, soil factors, crop conditions, and plant-soil diversity to optimize yields and agricultural productivity. Additionally, the evaluation of various agricultural practices such as sustainable agriculture, bio-economy, using technology can contribute to increased yields, profitability, and biodiversity conservation as central components of these practices. This study emphasizes that achieving the SDG objectives is attainable through agriculture, which has direct and indirect connections to all SDGs. Geospatial technology plays a vital role in supporting the objectives at spatial and temporal scales by facilitating agricultural practices, ensuring food security, preserving biodiversity, monitoring soil and crop conditions, and promoting sustainable development.
TL;DR: In this article , the effects of the dec2P384R mutation on animal health were investigated in a Drosophila model and it was shown that dec2p384R mutants lived significantly longer with improved health despite sleeping less.
Abstract: Sleep loss typically imposes negative effects on animal health. However, humans with a rare genetic mutation in the dec2 gene (dec2P384R) present an exception; these individuals sleep less without the usual effects associated with sleep deprivation. Thus, it has been suggested that the dec2P384R mutation activates compensatory mechanisms that allows these individuals to thrive with less sleep. To test this directly, we used a Drosophila model to study the effects of the dec2P384Rmutation on animal health. Expression of human dec2P384R in fly sleep neurons was sufficient to mimic the short sleep phenotype and, remarkably, dec2P384R mutants lived significantly longer with improved health despite sleeping less. The improved physiological effects were enabled, in part, by enhanced mitochondrial fitness and upregulation of multiple stress response pathways. Moreover, we provide evidence that upregulation of pro-health pathways also contributes to the short sleep phenotype, and this phenomenon may extend to other pro-longevity models.
TL;DR: In this paper , secondary metabolite-rich Solanum melongena L. (eggplant), one of the armyworm's hosts, was explored using a chemical ecology approach to discover a biopesticide against it.
Abstract: Lepidopteran pests are the major crop devastators. Farmers have to resort to heavy synthetic pesticide application for their control. It increases the pesticide residue contamination on produce and causes health hazards. Synthetic pesticides also endanger beneficial insects and pollute the environment. Therefore, the use of safe and eco-friendly botanicals as biopesticides is rapidly increasing. Despite their high demand, only a few botanicals are commercially available. Consequently, biopesticide discovery research boomed in the last decade. Spodoptera litura Fabricius (armyworm) is a polyphagous multi-insecticide-resistant lepidopteran pest. It is a serious concern for several commercially important crops. In this study, we employed a chemical ecology approach to discover a biopesticide against it. As a biopesticide source, we explored secondary metabolite-rich Solanum melongena L. (eggplant), one of the armyworm’s hosts. We found that the armyworm larvae show differential occurrence on seven eggplant varieties; the Himalayan eggplant variety RC-RL-22 (RL22) showed no armyworm infestation. When reared in a no-choice condition on RL22, larval mortality was two-fold higher, and mass was three-fold lower than the varieties showing high infestation. We tested whether RL22’s secondary metabolite(s) were associated with this hampered larval performance. Using LC-ESI-QTOF-based non-targeted metabolomics of eggplant varieties, we identified candidate metabolites. 5-O-caffeoylquinic acid (chlorogenic acid; CGA) showed a strong negative correlation (r= -0.88; p= 0.008) with the larval performance. CGA-spiked (average physiological concentration) artificial diet (CGA-AD)-fed larvae showed a three-fold mass reduction and two-fold mortality increase than the control artificial diet (AD)-fed larvae; pupation and eclosion also significantly reduced (1.3-fold and 1.4-fold, respectively) in the CGA-ingested larvae. We used a reverse genetics approach to assess the in planta insecticidal potential of CGA. When RL22’s CGA biosynthesis gene hydroxycinnamoyl-CoA quinate transferase (SmHQT) was silenced using virus-induced gene silencing (VIGS), CGA levels decreased by three-fold. This CGA depletion rendered RL22 two-fold armyworm-susceptible than controls. Foliar CGA application restored RL22’s armyworm resistance. Overall, this study showed that CGA exhibits larvicidal properties against the armyworm. It is also safe for beneficial organisms. CGA is a well-known dietary supplement and an antioxidant for humans. Thus, it is safe for human consumption. Together, high CGA-containing varieties can be used to reduce the armyworm infestation risk. CGA is a promising biopesticide candidate for the field trial phase against the lepidopteran pests, especially armyworm. If successful, it can be integrated into the pest control measures.
TL;DR: In this article , the authors describe a case of a female, who initially presented with hematuria and was later found to have multiple manifestations of the TSC, and emphasize the value of investigations on suspected cases.
Abstract: Tuberous sclerosis complex (TSC) is a rare genetic multisystem disorder that was first described by Von Recklinghausen. We describe a case of a female, who initially presented with hematuria and was later found to have multiple manifestations of the disease. The report emphasizes the value of investigations on suspected cases.
TL;DR: To rule out underlying developmental brain defects such as schizencephaly, pediatric seizures necessitate a thorough examination as mentioned in this paper , and imaging is critical to the diagnosis and therapy of such cases.
Abstract: To rule out underlying developmental brain defects such as schizencephaly, pediatric seizures necessitate a thorough examination. Adults who receive a diagnosis later in life may face severe management and prognosis difficulties. To avoid underdiagnosis of developing brain abnormalities, imaging should be a part of the workup for pediatric seizures. Imaging is critical to the diagnosis and therapy of such cases.
TL;DR: In this article , the effects of the dec2 P384R mutation on animal health were investigated in a Drosophila model and it was shown that dec2P384R mutants lived significantly longer with improved health despite sleeping less.
Abstract: Sleep loss typically imposes negative effects on animal health. However, humans with a rare genetic mutation in the dec2 gene ( dec2 P384R ) present an exception; these individuals sleep less without the usual effects associated with sleep deprivation. Thus, it has been suggested that the dec2 P384R mutation activates compensatory mechanisms that allows these individuals to thrive with less sleep. To test this directly, we used a Drosophila model to study the effects of the dec2 P384R mutation on animal health. Expression of human dec2 P384R in fly sleep neurons was sufficient to mimic the short sleep phenotype and, remarkably, dec2 P384R mutants lived significantly longer with improved health despite sleeping less. The improved physiological effects were enabled, in part, by enhanced mitochondrial fitness and upregulation of multiple stress response pathways. Moreover, we provide evidence that upregulation of pro-health pathways also contributes to the short sleep phenotype, and this phenomenon may extend to other pro-longevity models.
TL;DR: In this paper , the amount of pesticide residue after application of different organophosphate and carbamate insecticides in vegetable crops was evaluated using the Rapid Bioassay of Pesticide Residue technique.