P
Prisbe Ernest J
Publications - 53
Citations - 1299
Prisbe Ernest J is an academic researcher. The author has contributed to research in topics: Nucleoside & Phosphonate. The author has an hindex of 17, co-authored 53 publications receiving 1268 citations.
Papers
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Journal ArticleDOI
Practical Total Synthesis of the Anti-Influenza Drug GS-4104
John C. Rohloff,Kenneth M. Kent,Michael J. Postich,Becker Mark W,Chapman Harlan H,Daphne E Kelly,Willard Lew,Michael S. Louie,Lawrence R. McGee,Prisbe Ernest J,Lisa M. Schultze,Richard H. Yu,Lijun Zhang +12 more
Journal ArticleDOI
Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides.
Hans Maag,Robert M. Rydzewski,Mary Jane McRoberts,D. Crawford-Ruth,Julien P. H. Verheyden,Prisbe Ernest J +5 more
TL;DR: Reaction-mechanism considerations, empirical conformation rules, NMR-based conformational calculations, and NOE experiments suggest that the 4'-azidonucleosides prefer a 3'-endo (N-type) conformation of the furanose moiety.
Patent
Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
Becker Mark W,Chapman Harlan H,Tomas Cihlar,Eugene J. Eisenberg,He Gong-Xin,Kernan Michael R,William A. Lee,Prisbe Ernest J,John C. Rohloff,Sparacino Mark L +9 more
TL;DR: In this article, a method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify drugs selectively targeting desired tissues with antiviral or antitumor activity.
Journal ArticleDOI
Practical synthesis, separation, and stereochemical assignment of the pmpa pro-drug gs-7340
TL;DR: The practical synthesis of a mixed phenoxy-amidate derivative of PMPA with high oral bioavailability and favorable pharmacokinetics is described, using a non-stereoselective synthetic route.