The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

Chem. Pharm. Bull.(オピニオン)

Two-dimensionally extended, polycyclic heteroaromatic molecules (heterocyclic nanographenes) are a highly versatile class of organic materials, applicable as functional chromophores and organic semiconductors. In this Review, we discuss the rich chemistry of large heteroaromatics, focusing on their synthesis, electronic properties, and applications in materials science. This Review summarizes the historical development and current state of the art in this rapidly expanding field of research, which has become one of the key exploration areas of modern heterocyclic chemistry.

Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications

Cascade Processes of Metallo Carbenoids

Indoles in multicomponent processes (MCPs).

One-pot multi-component reaction of 3-cyanoacetyl indole, aromatic aldehydes and ethyl acetoacetate in the presence of \(\hbox {InCl}_{3}/\hbox {NH}_{4}\)OAc under microwave irradiation for 2–7 min afforded novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives, respectively, in good yield.

Microwave-assisted one-pot multi-component reaction: synthesis of novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives

Synthesis of Functionalized Dihydrofurocoumarin Derivatives from 3-Aminoalkyl-4-hydroxycoumarin

Functionalized annelated a-carbolines have been synthe- sized from oxindole following a tertiary amino effect reaction strat- egy.

The Tertiary Amino Effect:An Efficient Method for the Synthesis of α-Carbolines

Synthesis of some novel classes of quinolizine-, indolizine- and pyrido-1,4-oxazine-fused quinoline derivatives via a three-component reaction under solvent-free conditions by exploring the 'tertiary amine effect' reaction strategy.

α-Cyclisation of Tertiary Amines: Synthesis of Some Novel Annelated Quinolines via a Three-Component Reaction under Solvent-Free Conditions

6-(Tertiary amino)uracils 1 react with dimethyl acetylenedicarboxylate (DMAD) to afford 5,6-dihydropyrrolo[2,3-d]pyrimidines 3a and 3b and the tricyclic analogues 3c–fvia 1,5-electrocyclisation in excellent yields, whereas suitably functionalized uracil derivatives 5 undergo intramolecular 1,6-cycloaddition reactions to afford 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines 6a and 6b and the tricyclic analogues 6c–h in high yields.

Pulak J. Bhuyan

Papers

Microwave-assisted one-pot multi-component reaction: synthesis of novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives

Synthesis of Functionalized Dihydrofurocoumarin Derivatives from 3-Aminoalkyl-4-hydroxycoumarin

The Tertiary Amino Effect:An Efficient Method for the Synthesis of α-Carbolines

α-Cyclisation of Tertiary Amines: Synthesis of Some Novel Annelated Quinolines via a Three-Component Reaction under Solvent-Free Conditions

Studies on Uracils: Synthesis of Novel Uracil Analogues via 1,5- and 1,6-Intramolecular Cycloaddition Reactions