The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

Chem. Pharm. Bull.(オピニオン)

Two-dimensionally extended, polycyclic heteroaromatic molecules (heterocyclic nanographenes) are a highly versatile class of organic materials, applicable as functional chromophores and organic semiconductors. In this Review, we discuss the rich chemistry of large heteroaromatics, focusing on their synthesis, electronic properties, and applications in materials science. This Review summarizes the historical development and current state of the art in this rapidly expanding field of research, which has become one of the key exploration areas of modern heterocyclic chemistry.

Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications

Cascade Processes of Metallo Carbenoids

Indoles in multicomponent processes (MCPs).

Pyrimido[4,5- d ]pyrimidine derivatives 4 have been prepared in an efficient and regioselective manner in water via multi-component reaction of isothiocyanate 1 , aromatic aldehyde 2 , N,N -dimethyl-6-amino uracil 3 in the presence of p- toluenesulfonic acid ( p- TSA) as a Lewis acid catalyst.

An Efficient and Regioselective One-Pot Multi-Component Synthesis of Pyrimido[4,5-d]pyrimidine Derivatives in Water.

Synthesis of highly functionalized indeno[1,2-b]furans

Copper-catalyzed oxidative synthesis of 2-oxo-acetamidines from one-pot three-component reaction of aryl methyl ketones, secondary amines and anilines

5-Formyl-6-tertiaryamino uracils 3 prepared from 6-chloro-5-formyl uracil derivative 1 react with barbituric acids 4 in the presence of base catalyst to afford a novel class of spirosubstituted pyrido[2,3- d ]pyrimidines 5 via 1,6-electro-cyclisation in excellent yields.

Tertiary Amine Effect: Synthesis of Some Novel Spirosubstituted Pyrido[2,3‐d]pyrimidines.

Some novel 5-arylamino-pyrrolo[2,3-d]pyrimidine derivatives were synthesized via microwave-assisted three-component reaction of N,N-dimethyl-6-aminouracil, aryl glyoxal monohydrates and aryl amines. The products were obtained in good to excellent yields (82–91%) using a simple work-up procedure.

Pulak J. Bhuyan

Papers

An Efficient and Regioselective One-Pot Multi-Component Synthesis of Pyrimido[4,5-d]pyrimidine Derivatives in Water.

Synthesis of highly functionalized indeno[1,2-b]furans

Copper-catalyzed oxidative synthesis of 2-oxo-acetamidines from one-pot three-component reaction of aryl methyl ketones, secondary amines and anilines

Tertiary Amine Effect: Synthesis of Some Novel Spirosubstituted Pyrido[2,3‐d]pyrimidines.

A Novel One‐Pot Three‐Component Reaction for the Synthesis of 5‐Arylamino‐pyrrolo[2,3‐d]pyrimidines under Microwave Irradiation.