P
Pushpendra Singh
Researcher at Central University of Punjab
Publications - 14
Citations - 313
Pushpendra Singh is an academic researcher from Central University of Punjab. The author has contributed to research in topics: Docking (molecular) & Receptor tyrosine kinase. The author has an hindex of 6, co-authored 14 publications receiving 271 citations.
Papers
More filters
Journal ArticleDOI
Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer
TL;DR: A concerted effort to explore and fathom the well-recognized roles of the IRA signaling system in human cancer phenotype and the main strategies that have been so far evaluated to target the IR and IGF-1R.
Journal ArticleDOI
In silico molecular docking study of natural compounds on wild and mutated epidermal growth factor receptor
Pushpendra Singh,Felix Bast +1 more
TL;DR: This molecular docking study summarized docking free energy, protein–ligands interaction profile, and pharmacokinetic and pharmacodynamic parameter of lead molecules which were tremendously helpful in enhancing the activity of these natural compounds against EGFR.
Journal ArticleDOI
Screening and biological evaluation of myricetin as a multiple target inhibitor insulin, epidermal growth factor, and androgen receptor; in silico and in vitro.
Pushpendra Singh,Felix Bast +1 more
TL;DR: The results of MTT assay reveal that the myricetin inhibit the viability and proliferation of cancer cells in a dose-dependent manner.
Journal ArticleDOI
Multitargeted molecular docking study of plant-derived natural products on phosphoinositide-3 kinase pathway components
Pushpendra Singh,Felix Bast +1 more
TL;DR: The docking study carried out is an endeavor to portray the docking of these compounds with the proteins, to summarize the various Gscore, hydrogen bond, electrostatic bond, and to chart out various factors that are decisive for and also govern the protein–ligand interactions.
Journal ArticleDOI
Screening of multi-targeted natural compounds for receptor tyrosine kinases inhibitors and biological evaluation on cancer cell lines, in silico and in vitro
Pushpendra Singh,Felix Bast +1 more
TL;DR: Effect of EGCG on biological activity such as mRNA expression of selected protein, cell proliferation, oxidative stress, and cell migration was reported after the 48 h treatments in cancer cell lines and a reduction in the potential for cell migration that might show in vivo anti-metastasis activity of E GCG was indicated.