Q
Q. K. Fang
Researcher at Sunovion
Publications - 4
Citations - 100
Q. K. Fang is an academic researcher from Sunovion. The author has contributed to research in topics: D-amino acid oxidase & Receptor. The author has an hindex of 4, co-authored 4 publications receiving 95 citations.
Papers
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Journal ArticleDOI
Structural, Kinetic, and Pharmacodynamic Mechanisms of d-Amino Acid Oxidase Inhibition by Small Molecules
Seth C. Hopkins,Michelle L. R. Heffernan,Lakshmi D. Saraswat,Bowen Carrie A,L. Melnick,Larry W. Hardy,M. A. Orsini,Mike Allen,Patrick Koch,Kerry L. Spear,R. J. Foglesong,Mustapha Soukri,Milan Chytil,Q. K. Fang,Steven Jones,Mark A. Varney,A. Panatier,Stéphane H. R. Oliet,Loredano Pollegioni,Luciano Piubelli,Gianluca Molla,Marco Nardini,Thomas H. Large +22 more
TL;DR: DAAO inhibition increased the spatiotemporal influence of glial-derived d-serine, suggesting localized effects on neuronal circuits where DAAO can exert a neuromodulatory role.
Journal ArticleDOI
Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.
Ryan T. Terry-Lorenzo,Lawrence Chun,Scott P. Brown,Michelle L. R. Heffernan,Q. K. Fang,M. A. Orsini,Loredano Pollegioni,Larry W. Hardy,Kerry L. Spear,Thomas H. Large +9 more
TL;DR: The results confirm previous hypotheses regarding active-site lid flexibility of mammalian D-amino acid oxidases and could assist in the design of the next generation of hDAAO inhibitors.
Patent
Fused heterocyclic inhibitors of d-amino acid oxidase
James M. Dorsey,Q. K. Fang,Robert J. Foglesong,Michele L. R. Heffernan,Seth C. Hopkins,Michael L. Jones,Steven Jones,Ogbu Cyprian O,Joe B. Perales,Mustapha Soukri,Kerry L. Spear,Mark A. Varney +11 more
TL;DR: In this article, the authors provided novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention, and also provided methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, and pain, ataxia and convulsion.
Patent
Inhibitors of d-amino acid oxidase
Michele L. R. Heffernan,Q. K. Fang,Robert J. Foglesong,Seth C. Hopkins,Ogbu Cyprian O,Mustapha Soukri,Kerry L. Spear +6 more
TL;DR: In this paper, the authors proposed novel inhibitors of the enzyme D- amino acid oxidase, which are useful for treating or preventing diseases and conditions, wherein modulation of D- serine levels, and/or its oxidative products, is effective in ameliorating symptoms.