Thomas H. Large

TL;DR: The discovery and pharmacology of SEP-856 is described, a novel psychotropic agent that does not exert its antipsychotic-like effects through direct interaction with D2 receptors and suggests that agonism at both trace amine-associated receptor 1 and 5-HT1A receptors is integral to its efficacy.

TL;DR: How functional imaging-derived information on activity in pain-processing brain regions could have predicted that NK-1RAs would have a low probability of success in this therapeutic domain is discussed.

TL;DR: DAAO inhibition increased the spatiotemporal influence of glial-derived d-serine, suggesting localized effects on neuronal circuits where DAAO can exert a neuromodulatory role.

TL;DR: The results confirm previous hypotheses regarding active-site lid flexibility of mammalian D-amino acid oxidases and could assist in the design of the next generation of hDAAO inhibitors.

TL;DR: The upper and lower confidence interval CI bounds reported herein could be utilized in subsequent trials involving healthy volunteers to hypothesize the magnitude of effect required to overcome inherent variability of either VAS pain ratings or BOLD responses evoked during innocuous or noxious thermal stimulation.