Q
Qi Chen
Researcher at University of Texas Southwestern Medical Center
Publications - 3
Citations - 789
Qi Chen is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: TAL1 & Chromosomal translocation. The author has an hindex of 3, co-authored 3 publications receiving 777 citations.
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Journal ArticleDOI
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Qi Chen,Jiin Tsuey Cheng,L.H. Tasi,Nancy R. Schneider,George R. Buchanan,AJ Carroll,W. Crist,B. Ozanne,M. Siciliano,Richard Baer +9 more
TL;DR: Analysis of t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia has identified sequences within tal that potentially encode an amphipathic helix‐loop‐helix motif, a DNA‐binding domain found in a variety of proteins that control cell growth and differentiation.
Journal ArticleDOI
Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.
Lamorna Brown,Jiin Tsuey Cheng,Qi Chen,Michael J. Siciliano,William M. Crist,William M. Crist,George R. Buchanan,Richard Baer +7 more
TL;DR: T(1;14)(p32;q11) translocations and tald rearrangements disrupt the coding potential of tal‐1 in an equivalent manner, and thereby generate a common genetic lesion shared by a significant proportion of T‐ALL patients.
Journal ArticleDOI
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.
TL;DR: Analysis of the tal-1 gene product reveals that its HLH domain mediates protein-protein interactions with either of the ubiquitously expressed HLH proteins E47 and E12, which suggest that HLH heterodimers involving tal- 1 may function in vivo as transcriptional regulatory factors that influence cell type determination during hematopoietic development.