Qi-Gang Zhou

TL;DR: This protocol describes how to carry out the sucrose preference test (SPT) in a standardized way to reduce data variability and provides a detailed protocol to ensure greater consistency when carrying out SPT.

TL;DR: This drug blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion and reperfusion.

TL;DR: It is suggested that nNOS over‐expression in the hippocampus is essential for chronic stress‐induced depression and inhibiting nN OS signaling in brain may represent a novel approach for the treatment of depressive disorders.

TL;DR: It is suggested that chronic fluoxetine treatment benefits spatial cognitive function recovery following ischemic insult, and the improved cognitive function is associated with enhanced newborn cell survival in the hippocampus.

TL;DR: It is shown that 5-HT1AR-selective agonist 8-OH-DPAT and selective serotonin reuptake inhibitor (SSRI) fluoxetine downregulated hippocampal neuronal nitric oxide synthase (nNOS) expression, whereas NAN-190 upregulated hippocampusal nNOS expression, indicating that both hippocampal n NOS and CREB activity mediate the anxiolytic effects of 5- HT1AR agonists and SSRIs.