Q
Qi Song
Publications - 5
Citations - 277
Qi Song is an academic researcher. The author has contributed to research in topics: Hydrophilic interaction chromatography & Tandem mass spectrometry. The author has an hindex of 5, co-authored 5 publications receiving 271 citations.
Papers
More filters
Journal ArticleDOI
Critical Review of Development, Validation, and Transfer for High Throughput Bioanalytical LC-MS/MS Methods
TL;DR: Strategic approaches for developing and validating robust high throughput LC-MS/MS methods, including automated sample preparation, fast chromatography, minimization of matrix effects, and strategy of narrowing the gap between validation and incurred sample analysis are covered in this review.
Journal ArticleDOI
Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS)--eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction.
Qi Song,Weng Naidong +1 more
TL;DR: A novel approach of eliminating these two steps in 96-well LLE by using hydrophilic interaction chromatography with MS/MS (HILIC-MS/MS) on silica column with high organic/low aqueous mobile phase is demonstrated.
Journal ArticleDOI
Automated 96-well solid phase extraction and hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the analysis of cetirizine (ZYRTEC) in human plasma--with emphasis on method ruggedness.
Qi Song,Heiko Junga,Yong Tang,Austin C. Li,Tom Addison,Melanie McCort-Tipton,Brian D. Beato,Weng Naidong +7 more
TL;DR: This high-throughput bioanalytical method based on automated sample transfer, automated solid phase extraction, and hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) analysis, has been developed and was successfully used to support clinical studies.
Journal ArticleDOI
Development, validation and transfer of a hydrophilic interaction liquid chromatography/tandem mass spectrometric method for the analysis of the tobacco-specific nitrosamine metabolite NNAL in human plasma at low picogram per milliliter concentrations
TL;DR: A highly sensitive bioanalytical method based on a simple liquid/liquid extraction and hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC/MS/MS) analysis has been developed, validated and transferred for the determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a tobacco-specific nitrosamine metabolite.