Qiang Gao

TL;DR: A robust PEGylated cationic amphiphilic peptides-based bottlebrush-like surface coating is demonstrated here, which fulfil the requirements of antimicrobial and antifouling as well as biocompatibility in the meantime.

TL;DR: This dual-functional polymer brush coating can be immobilized on the surface of multiple categories of materials through the mussel-inspired pDA coating, and thus should be widely applicable for combating infection in many classes of bio-medical materials.

TL;DR: In this article, block copolymers consisting of antimicrobial, antifouling, and surface-tethering segments in one molecule are synthesized and grafted on polymeric substrates by a facile plasma/autoclave-assisted method.

TL;DR: A series of cationic peptidopolysaccharides that have a bacterial peptidoglycan-mimetic structure and have been synthesized using a facile thiol–ene ‘click’ chemistry to graft antimicrobial peptides, e-poly-L-lysine (EPL), onto a polysaccharide (chitosan, CS) backbone demonstrate strong antimicrobial efficacy and present a promising prospect for CS-g-EPL in biomedical applications.

TL;DR: The results support the clinical potential of this cationic polypeptide (Pep)-functionalized biomimetic nanostructure coating as a new approach with desirable antibacterial properties and HAp-forming ability in orthopedic and dental applications.