Journal ArticleDOI
Methacrylate-ended polypeptides and polypeptoids for antimicrobial and antifouling coatings
TLDR
This dual-functional polymer brush coating can be immobilized on the surface of multiple categories of materials through the mussel-inspired pDA coating, and thus should be widely applicable for combating infection in many classes of bio-medical materials.About:
This article is published in Polymer Chemistry.The article was published on 2017-10-24. It has received 85 citations till now. The article focuses on the topics: Polymer brush & Coating.read more
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Smart Antibacterial Surfaces with Switchable Bacteria-Killing and Bacteria-Releasing Capabilities
TL;DR: A promising "kill-release" strategy has been proposed and applied to construct so-called smart antibacterial surfaces, which can kill bacteria attached to their surface and then undergo on-demand release of the dead bacteria and other debris to reveal a clean surface under an appropriate stimulus, thereby maintaining effective long-term antibacterial activity.
Journal ArticleDOI
Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections.
TL;DR: In this article, the photothermal therapy (PTT)-derived multimodal synergistic treatments have received wide attention and exhibited cooperatively enhanced bactericidal activity, which could solve the currently existing sterilization deficiencies of other combined therapeutic modes, for example, bacterial resistance for chemotherapy, low drug permeability for PDT/PCT/SDT, adverse immunoreactions for immunotherapy, etc.
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Synthesis, Self-Assembly, and Biomedical Applications of Antimicrobial Peptide–Polymer Conjugates
TL;DR: This Perspective seeks to highlight the state-of-the-art strategy for the synthesis, self-assembly, and biomedical applications of AMP-polymer conjugates and explore the promising directions for future research ranging from synthetic strategies, multistage and stimuli-responsive antibacterial activities, antifungi applications, and potentials in elimination of inflammation during medical treatment.
Journal ArticleDOI
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.
Alicia Rasines Mazo,Stephanie Allison-Logan,Fatemeh Karimi,Fatemeh Karimi,Nicholas Jun-An Chan,Wenlian Qiu,Wei Duan,Neil M O'Brien-Simpson,Greg G. Qiao +8 more
TL;DR: Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the wide range of applications towards which polypeptides have been applied.
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Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug-Resistant Bacteria.
TL;DR: The "state-of-the-art" biodegradable antibacterial polymeric nanosystems, which could respond to bacteria environments (e.g., acidity or bacterial enzymes) for controlled antibiotic release or multimodal antibacterial treatment, are summarized.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Biofilms: an emergent form of bacterial life.
Hans-Curt Flemming,Jost Wingender,Ulrich Szewzyk,Peter D. Steinberg,Scott A. Rice,Staffan Kjelleberg +5 more
TL;DR: The fundamental role of the biofilm matrix is considered, describing how the characteristic features of biofilms — such as social cooperation, resource capture and enhanced survival of exposure to antimicrobials — all rely on the structural and functional properties of the matrix.
Tackling drug-resistant infections globally: final report and recommendations
TL;DR: Suggested reading taken from the last 12 months of the Commission’s weekly publication “On the Radar” highlights papers and reporting exploring the evidence for the effectiveness of antimicrobial stewardship in hospitals, the scope of the problem of antimacterial resistance, and some specific stewardship strategies.
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Understanding biofilm resistance to antibacterial agents.
TL;DR: The mechanisms that underlie biofilm resistance to antimicrobial chemotherapy will be examined, with particular attention being given to potential avenues for the effective treatment of biofilms.
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Antibacterial drug discovery in the resistance era
Eric D. Brown,Gerard D. Wright +1 more
TL;DR: The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large as discussed by the authors, and the evolution and widespread distribution of antibiotic-resistant elements in bacterial pathogens has made diseases that were once easily treatable deadly again.