Q
Qing Shi
Researcher at Fudan University
Publications - 15
Citations - 279
Qing Shi is an academic researcher from Fudan University. The author has contributed to research in topics: Ubiquitin ligase & Biology. The author has an hindex of 5, co-authored 8 publications receiving 96 citations.
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Journal ArticleDOI
Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
Qing Shi,Yasheng Zhu,Jian Ma,Kun Chang,Dongling Ding,Yang Bai,Kun Gao,Pingzhao Zhang,Ren Mo,Kai Feng,Xiaying Zhao,Liang Zhang,Huiru Sun,Dongyue Jiao,Y Chen,Yinghao Sun,Shimin Zhao,Haojie Huang,Yao Li,Shancheng Ren,Chenji Wang +20 more
TL;DR: SG assembly is aberrantly elevated in SPOP-mutated prostate cancer and the role of SPOP mutations in aberrant activation of the SG in prostate cancer is investigated and the relevanve of the mechanism in therapy resistance is explored.
Journal ArticleDOI
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Jian Ma,Kun Chang,Jingtao Peng,Qing Shi,Hualei Gan,Kun Gao,Kai Feng,Fujiang Xu,Hailiang Zhang,Bo Dai,Yao Zhu,Guohai Shi,Yijun Shen,Yiping Zhu,Xiaojian Qin,Yao Li,Pingzhao Zhang,Dingwei Ye,Chenji Wang +18 more
TL;DR: SPOP promotes ATF2 ubiquitination and degradation, and ATF2 is an important mediator of SPOP inactivation-induced cell proliferation, migration and invasion, and is identified as a bona fide substrate of the SPOP-CUL3-RBX1 E3 ubiquitin ligase complex.
Journal ArticleDOI
CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling.
Xiaofeng Jin,Qing Shi,Qian Li,Linyi Zhou,Jian Wang,Lei Jiang,Xiaying Zhao,Kai Feng,Ting Lin,Zihan Lin,Hui Zhuang,Jianye Yang,Chongke Hu,Luyi Zhang,Liliang Shen,Ying Lu,Jie Zhu,Haibiao Wang,Honggang Qi,Xiaodan Meng,Yang Xi,Jinchang Pan,Shuai Fang,Haihua Tian,Chengwei Zhou,Pingzhao Zhang,Kun Gao,Shimin Zhao,Yao Li,Zhaohui Gong,Chenji Wang +30 more
TL;DR: It is revealed that SPOP binds to and induces the nondegradative ubiquitination of MyD88 by recognizing an atypical SPOP-binding motif in MyD 88, which suppresses DLBCL cell growth in vitro and tumor xenograft in vivo by inhibiting the MyD87/NF-κB signaling.
Journal Article
ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.
Jiantao Xiao,Qing Shi,Weiguo Li,Xingyu Mu,Jintao Peng,Mingzi Li,Mulin Chen,Huabing Huang,Chenji Wang,Kun Gao,Jie Fan +10 more
TL;DR: A novel mechanism for ARRDC1/3 in the regulation of YAP1 stability is revealed and insight is provided in understanding the relationship between ARR DC3/3 downregulation and aberrant Hippo-YAP1 pathway activation in ccRCC.