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Shimin Zhao
Researcher at Fudan University
Publications - 86
Citations - 15023
Shimin Zhao is an academic researcher from Fudan University. The author has contributed to research in topics: Acetylation & Chemistry. The author has an hindex of 34, co-authored 73 publications receiving 11865 citations. Previous affiliations of Shimin Zhao include Fudan University Shanghai Medical College & Novartis.
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Journal ArticleDOI
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu,Hui Yang,Ying Liu,Ying Yang,Ping Wang,Se Hee Kim,Shinsuke Ito,Chen Yang,Pu Wang,Meng Tao Xiao,Li Xia Liu,Wen Qing Jiang,Jing Liu,Jin Ye Zhang,Bin Wang,Stephen V. Frye,Yi Zhang,Yanhui Xu,Qun-Ying Lei,Kun-Liang Guan,Shimin Zhao,Yue Xiong +21 more
TL;DR: 2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases, leading to genome-wide histone and DNA methylation alterations.
Journal ArticleDOI
Regulation of cellular metabolism by protein lysine acetylation.
Shimin Zhao,Wei Xu,Wenqing Jiang,Wei Yu,Yan Lin,Tengfei Zhang,Jun Yao,Li Zhou,Yaxue Zeng,Hong Li,Yixue Li,Jiong Shi,Wenlin An,Susan M. Hancock,Fuchu He,Lunxiu Qin,Jason W. Chin,Pengyuan Yang,Xian Chen,Xian Chen,Qun-Ying Lei,Yue Xiong,Yue Xiong,Kun-Liang Guan +23 more
TL;DR: It is revealed that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism, and plays a major role in metabolic regulation.
Journal ArticleDOI
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Gommaar D'Hulst,Inés Soro-Arnaiz,Evi Masschelein,Koen Veys,Gillian Fitzgerald,Benoit Smeuninx,Sunghoon Kim,Louise Deldicque,Bert Blaauw,Peter Carmeliet,Leigh Breen,Peppi Koivunen,Shimin Zhao,Shimin Zhao,Katrien De Bock +14 more
TL;DR: The authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner and prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucines.
Journal ArticleDOI
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Shimin Zhao,Yan Lin,Wei Xu,Wenqing Jiang,Zhengyu Zha,Pu Wang,Wei Yu,Zhiqiang Li,Lingling Gong,Yingjie Peng,Jianping Ding,Qun-Ying Lei,Kun-Liang Guan,Kun-Liang Guan,Yue Xiong,Yue Xiong +15 more
TL;DR: IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
Journal ArticleDOI
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.
Qijun Wang,Yakun Zhang,Chen Yang,Hui Xiong,Hui Xiong,Yan Lin,Jun Yao,Hong Li,Lu Xie,Wei Zhao,Yu-Feng Yao,Zhibin Ning,Rong Zeng,Yue Xiong,Yue Xiong,Kun-Liang Guan,Kun-Liang Guan,Shimin Zhao,Guoping Zhao +18 more
TL;DR: It is demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux.