X
Xiaying Zhao
Researcher at Fudan University
Publications - 4
Citations - 131
Xiaying Zhao is an academic researcher from Fudan University. The author has contributed to research in topics: Ubiquitin ligase & SPOP. The author has an hindex of 2, co-authored 4 publications receiving 39 citations.
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Journal ArticleDOI
Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
Qing Shi,Yasheng Zhu,Jian Ma,Kun Chang,Dongling Ding,Yang Bai,Kun Gao,Pingzhao Zhang,Ren Mo,Kai Feng,Xiaying Zhao,Liang Zhang,Huiru Sun,Dongyue Jiao,Y Chen,Yinghao Sun,Shimin Zhao,Haojie Huang,Yao Li,Shancheng Ren,Chenji Wang +20 more
TL;DR: SG assembly is aberrantly elevated in SPOP-mutated prostate cancer and the role of SPOP mutations in aberrant activation of the SG in prostate cancer is investigated and the relevanve of the mechanism in therapy resistance is explored.
Journal ArticleDOI
CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling.
Xiaofeng Jin,Qing Shi,Qian Li,Linyi Zhou,Jian Wang,Lei Jiang,Xiaying Zhao,Kai Feng,Ting Lin,Zihan Lin,Hui Zhuang,Jianye Yang,Chongke Hu,Luyi Zhang,Liliang Shen,Ying Lu,Jie Zhu,Haibiao Wang,Honggang Qi,Xiaodan Meng,Yang Xi,Jinchang Pan,Shuai Fang,Haihua Tian,Chengwei Zhou,Pingzhao Zhang,Kun Gao,Shimin Zhao,Yao Li,Zhaohui Gong,Chenji Wang +30 more
TL;DR: It is revealed that SPOP binds to and induces the nondegradative ubiquitination of MyD88 by recognizing an atypical SPOP-binding motif in MyD 88, which suppresses DLBCL cell growth in vitro and tumor xenograft in vivo by inhibiting the MyD87/NF-κB signaling.
Journal ArticleDOI
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation.
Pingzhao Zhang,Kun Gao,Liang Zhang,Huiru Sun,Xiaying Zhao,Yajuan Liu,Zeheng Lv,Qing Shi,Y Chen,Dongyue Jiao,Yao Li,Wei Gu,Chenji Wang +12 more
TL;DR: In this paper, the Cullin 2 RING E3 ligase (CRL2)-KLHDC3 E3 ubiquitin ligase complex was shown to regulate p14ARF protein stability.
Journal ArticleDOI
Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex.
Liang Zhang,Jianong Zhang,Yan Liu,Pingzhao Zhang,Ji Nie,Rui Zhao,Qin Shi,Huiru Sun,Dongyue Jiao,Y Chen,Xiaying Zhao,Yan Huang,Yao Li,Jian-Yuan Zhao,Wei Xu,Shimin Zhao,Chenji Wang +16 more
TL;DR: In this paper, the authors show that a fraction of the signal transducer and activator 5a (STAT5A) is localized in the mitochondria, but the biological functions of mitochondrial STAT5A remain obscure.