Q
Qingzhou Yao
Researcher at University of Colorado Denver
Publications - 17
Citations - 158
Qingzhou Yao is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 11 publications receiving 103 citations.
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Journal ArticleDOI
Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways
Qiong Zhan,Rui Song,Qingchun Zeng,Qingzhou Yao,Lihua Ao,Dingli Xu,David A. Fullerton,Xianzhong Meng +7 more
TL;DR: DSRNA, when present in aortic valve tissue, may promote CAVD progression through up-regulation of AVIC osteogenic activities and the mechanism of its action is suggested to be TLR3 and the NF-κB and ERK1/2 pathways.
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Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9
Fei Li,Fei Li,Qingzhou Yao,Lihua Ao,Joseph C. Cleveland,Nianguo Dong,David A. Fullerton,Xianzhong Meng +7 more
TL;DR: It is concluded that high Pi induces human AVIC osteogenic responses through Sox9 and Klotho suppresses the pro-osteogenic effect of high Pi on human AV ICs, indicating that modulation of KlothO may have therapeutic potential for mitigation of valvular calcification associated with CKD.
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Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis
TL;DR: NT3 is a profibrogenic mediator in human aortic valve, and overproduction of NT3 by aortIC valve tissue may contribute to the mechanism of valvular sclerosis.
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Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip
Peng Zhao,Qingzhou Yao,Peijian Zhang,Yufeng Zhai,Lihua Ao,Michael Jarrett,Charles A. Dinarello,David A. Fullerton,Xianzhong Meng +8 more
TL;DR: In this article, a three-dimensional microengineered human coronary artery-on-a-chip was developed for investigation of the mechanism by which low and oscillatory shear stress (OSS) induces pro-atherogenic changes.
Journal ArticleDOI
Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells.
TL;DR: LysoPC upregulates the production of biglycan and collagen I in human AVICs and may mediate the effect of oxLDL on ECM protein production, which appears to be critical in mediating theeffect of LysoPC.