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Xianzhong Meng
Researcher at University of Colorado Denver
Publications - 225
Citations - 8716
Xianzhong Meng is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Tumor necrosis factor alpha & Ischemia. The author has an hindex of 50, co-authored 213 publications receiving 7964 citations. Previous affiliations of Xianzhong Meng include Shantou University & University of Colorado Boulder.
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Journal ArticleDOI
Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C
TL;DR: The results suggest that PKC is an effector of preconditioning in the isolated rat heart and transient ischemia and alpha 1-adrenergic receptor-induced preconditionsing is inhibited by protein kinase C (PKC) antagonists.
Journal ArticleDOI
Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function.
Brian S. Cain,Daniel R. Meldrum,Charles A. Dinarello,Xianzhong Meng,Kyung S. Joo,Anirban Banerjee,Alden H. Harken +6 more
TL;DR: Therapeutic strategies to reduce production or signaling of either TNF-alpha or IL-1beta may limit myocardial dysfunction in sepsis, and together, these cytokines act synergistically to depress humanMyocardial function.
Journal ArticleDOI
Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion
Kirstan K. Donnahoo,Xianzhong Meng,Alfred Ayala,Mark P. Cain,Alden H. Harken,Daniel R. Meldrum +5 more
TL;DR: The initial demonstration that early renal tissue TNF expression contributes to neutrophil infiltration and injury after I/R and TNF-BP may offer a new adjunctive therapy in renal preservation prior to planned ischemic insults is demonstrated.
Journal ArticleDOI
Mycobacterium tuberculosis Induces Interleukin-32 Production through a Caspase- 1/IL-18/Interferon-γ-Dependent Mechanism
Mihai G. Netea,Tania Azam,Eli C. Lewis,Leo A. B. Joosten,Maorong Wang,Dennis M. L. Langenberg,Xianzhong Meng,Edward D. Chan,Do-Young Yoon,Tom H. M. Ottenhoff,Soohyun Kim,Soohyun Kim,Charles A. Dinarello +12 more
TL;DR: IL-32 is a cell-associated proinflammatory cytokine, which is specifically stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of IFNγ.
Journal ArticleDOI
Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis.
Xianzhong Meng,Lihua Ao,Yong Song,Ashok N. Babu,Xiaoping Yang,Maorong Wang,Michael J. Weyant,Charles A. Dinarello,Joseph C. Cleveland,David A. Fullerton +9 more
TL;DR: It is demonstrated for the first time that HAVICs express TLR2 and TLR4 and that stimulation of HAVics by PGN or LPS induces the expression of proinflammatory mediators and the upregulation of osteogenesis-associated factors.