Q
Qiqi Shi
Researcher at Sir Run Run Shaw Hospital
Publications - 15
Citations - 193
Qiqi Shi is an academic researcher from Sir Run Run Shaw Hospital. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 4, co-authored 4 publications receiving 121 citations.
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Journal ArticleDOI
Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer
Xiaoling Qian,Wenxia Xu,Jinye Xu,Qiqi Shi,Jiaqiu Li,Yu Weng,Zhinong Jiang,Lifeng Feng,Xian Wang,Jianwei Zhou,Hongchuan Jin +10 more
TL;DR: ENO1 is a novel biomarker to predict drug resistance and overall prognosis in gastric cancer and Targeting ENO1 by chemical inhibitors or up-regulating miR-22 could be valuable to overcome drug resistance.
Journal ArticleDOI
SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer
Neelum Aziz Yousafzai,Qiyin Zhou,Wenxia Xu,Qiqi Shi,Jinye Xu,Lifeng Feng,Hui Chen,Vivian Y. Shin,Hongchuan Jin,Xian Wang +9 more
TL;DR: SIRT1 confers chemoresistance to lung cancer cells by deacetylating and stabilizing XRCC1 and targeting SIRT1 might be a new strategy to manage theChemoresistance of lung cancer, and probably other cancers.
Journal ArticleDOI
Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance.
Jinye Xu,Qiqi Shi,Wenxia Xu,Qiyin Zhou,Rongkai Shi,Yanning Ma,Dingwei Chen,Liyuan Zhu,Lifeng Feng,Alfred S. L. Cheng,Helen Morrison,Xian Wang,Hongchuan Jin +12 more
TL;DR: PDK3 forms a positive feedback loop with HSF1 to drive glycolysis in chemoresistance, and targeting this mitonuclear communication may represent a novel approach to overcome Chemoresistance.
Journal Article
Rab5a suppresses autophagy to promote drug resistance in cancer cells.
Wenxia Xu,Qiqi Shi,Xiaoling Qian,Bingluo Zhou,Jinye Xu,Liyuan Zhu,Lifeng Feng,Hongchuan Jin,Xian Wang +8 more
TL;DR: It is found that in cisplatin-resistant cells, knockdown of Rab5a activated autophagy via mTOR pathway and could reverse drug resistance while overexpression of Rab 5a in drug sensitive cells increased drug tolerance.
Journal ArticleDOI
KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling
Bo Yu,Jun Su,Qiqi Shi,Qing Liu,Jun Ma,Guo-Qing Ru,Lei Zhang,Jian Zhang,Xichun Hu,Jianming Tang +9 more
TL;DR: Wang et al. as discussed by the authors identified that SNIP1 is a non-histone substrate of lysine methyltransferase KMT5A, which undergoes KMT 5A-mediated mono-methylation to promote breast cancer cell growth, invasion and lung metastasis.