Alfred S. L. Cheng

TL;DR: The first metagenomic profiling study of CRC faecal microbiomes is presented to discover and validate microbial biomarkers in ethnically different cohorts, and to independently validate selected biomarkers using an affordable clinically relevant technology.

TL;DR: Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation.

TL;DR: Reconstitution of miR-29 in RMS in mice inhibits tumor growth and stimulates differentiation, suggesting that mi R-29 acts as a tumor suppressor through its promyogenic function.

TL;DR: Intensity of COX-2 was not significantly different between the chronic active gastritis, gastric atrophy, IM, and gastric adenocarcinoma groups, and in 17 patients with IM, COx-2 expressions in the epithelial cells and stromal cells were reduced 1 year after H. pylori eradication, but changed did not correlate with progression/regression of IM.

TL;DR: An in-depth understanding of the molecular changes specific to acquired resistance to clinically important antiestrogens is provided, which could allow for identification of therapy targets and strategies for resensitization to these well-established antihormonal agents.