Q
Quanbo Xiong
Researcher at Rice University
Publications - 13
Citations - 669
Quanbo Xiong is an academic researcher from Rice University. The author has contributed to research in topics: Sterol & Aspergillus fumigatus. The author has an hindex of 10, co-authored 13 publications receiving 610 citations. Previous affiliations of Quanbo Xiong include Texas Southern University.
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Journal ArticleDOI
An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis.
Silvia Lodeiro,Quanbo Xiong,William K. Wilson,Mariya D. Kolesnikova,Carl S. Onak,Seiichi P. T. Matsuda +5 more
TL;DR: It is suggested that mechanistic diversity is the default for triterpene biosynthesis and that product accuracy results from exclusion of alternative pathways.
Journal ArticleDOI
Mechanistic insights into triterpene synthesis from quantum mechanical calculations. Detection of systematic errors in B3LYP cyclization energies
TL;DR: This work calculated mPW1PW91/6-311+G(2d,p)//B3LYP/ 6-31G* energies to establish the first comprehensive energy profiles for the cationic cyclization of oxidosqualene to lanosterol, lupeol, and hopen-3beta-ol to reveal systematic errors in DFT cyclization energies.
Journal ArticleDOI
Lanosterol biosynthesis in plants.
TL;DR: Phylogenetic reconstructions reveal that lanosterol synthases are broadly distributed in eudicots but evolved independently from those in animals and fungi, and novel catalytic motifs establish that plant lanosterl synthases comprise a third catalytically distinct class of lanosterols synthase.
Journal ArticleDOI
An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation.
Journal ArticleDOI
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus.
Silvia Lodeiro,Quanbo Xiong,William K. Wilson,Yulia Ivanova,McKenzie L. Smith,Gregory S. May,Seiichi P. T. Matsuda +6 more
TL;DR: During product characterization of oxidosqualene cyclases in Aspergillus fumigatus, it is found the long-sought cyclase that makes (17Z)-protosta-17(20),24-dien-3beta-ol, the precursor of helvolic acid.