Quigly Dragotakes

TL;DR: This essay focuses on the capsule of Cryptococcus neoformans as a cellular structure and notes the limitations inherent in the current methodologies available for its study.

TL;DR: Modulation of PMP is a critical event in determining the outcome of C. neoformans–macrophage interaction, and Capsular enlargement inside macrophages was identified as an additional likely mechanism for phagolysosomal membrane damage.

TL;DR: In this article, a strong inverse correlation between CCP use and mortality per admission in the USA provides population-level evidence consistent with the notion that CCP reduces mortality in COVID-19 and suggests that the recent decline in usage could have resulted in excess deaths.

TL;DR: It is proposed that macrophage cell-to-cell transfer represents a nonlytic exocytosis event, followed by phagocytotic into a macrophages that is in close proximity, and name this process Dragotcytosis (“Dragot” is a Greek surname meaning “sentinel”), as it represents sharing of a microbe between two sentinel cells of the innate immune system.

TL;DR: By stochastically acidifying a phagolysosome to a pH within the observed distribution, macrophages sacrificed a small amount of overall fitness to reduce their overall variation in fitness, which implies a bet-hedging strategy that benefits the macrophage.