R
R E Schmidt
Researcher at Harvard University
Publications - 18
Citations - 1725
R E Schmidt is an academic researcher from Harvard University. The author has contributed to research in topics: Natural killer cell & Antigen. The author has an hindex of 14, co-authored 18 publications receiving 1714 citations.
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Journal ArticleDOI
Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein.
TL;DR: It is shown that T11 triggering can activate cytotoxic lymphocytes to express their functional programmes in the absence of specific antigen recognition via the T3–Ti complex and provide further evidence for the notion that certain NK cells and T lymphocytes are related.
Journal ArticleDOI
Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes.
Thierry Hercend,James D. Griffin,Armand Bensussan,R E Schmidt,Mary Ann Edson,Agnes Brennan,Christopher J L Murray,Jennifer Daley,Stuart F. Schlossman,Jerome Ritz +9 more
TL;DR: Results strongly supported the view that NKH1A is a "pan-NK" associated antigen, and indicated that at least a fraction of cloned NKH2 + LGL are strongly cytotoxic.
Journal ArticleDOI
A subset of natural killer cells in peripheral blood displays a mature T cell phenotype.
TL;DR: Results indicate that NKH1+T3+ cells represent a unique population of NK-active cells in normal peripheral blood, and this appears to be mediated through a functional T cell-like receptor for target antigen.
Book ChapterDOI
Characterization of functional surface structures on human natural killer cells.
TL;DR: Findings provide strong evidence that NKH1+CD3- NK clones do not interact with target cells through a T cell receptor-like structure, and subsets of cytolytic cells with distinct functional repertoires and distinct cy tolytic mechanisms are identified.
Journal ArticleDOI
Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.
Jerome Ritz,Thomas J. Campen,R E Schmidt,Hans Dieter Royer,Thierry Hercend,Rebecca E. Hussey,Ellis L. Reinherz +6 more
TL;DR: Since previous studies demonstrated that Ti beta gene activation precedes Ti alpha gene activation in thymic ontogeny, the T11+T3- NK cells appear to be derived from T-lineage precursors.