R. Goodnow

TL;DR: The effects of spermine and a synthetic analogue (PhTX-343) of the polyamine amide toxin, delta-philanthotoxin, on the responses of Xenopus oocytes to application of amino acids were examined using voltage clamp to discuss the postulated polyamine binding site on the N-methyl-D-aspartate receptor.

TL;DR: Fifty-two analogues of the wasp toxin, philanthotoxin-433, have been synthesized and tested on a glutamatergic, nerve-muscle preparation from locust leg and showed increased hydrophobicity of aromatic and tyrosyl regions and an increased number of protonated groups in the polyamine region.

TL;DR: The synthesis of the non-competative glutamate receptor inhibitor, philanthotoxin 433 (PhTX-433) is described and two synthetic routes are described for the preparation of a variety of structural analogs.

TL;DR: This toxin, philanthotoxin-433 (PhTX-433), having a butyryl/tyrosyl/polyamine structure, is a potent noncompetitive inhibitor of the quisqualate sub-type glutamate receptor as assayed by the twitch contraction of locust leg muscles.

TL;DR: It was found that PhTX analogues with photoaffinity labels may be useful in the isolation/purification of various glutamate and nicotinic acetylcholine receptors; they could also been useful in structural studies of receptors and their binding sites.