Calbindin D-28k and parvalbumin in the rat nervous system

Mitochondria and calcium ion transport.

The effects of a vitamin D deficiency on insulin and glucagon release was determined in the isolated perfused rat pancreas by radioimmunoassay of the secreted proteins. During a 30-minute period of perfusion with glucose and arginine, pancreases from vitamin D-deficient rats exhibited a 48 percent reduction in insulin secretion compared to that for pancreases from vitamin D-deficient rats that had been replenished with vitamin D. Vitamin D status had no effect on pancreatic glucagon secretion. This result, along with the previously demonstrated presence in the pancreas of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, indicates an important role for vitamin D in the endocrine functioning of the pancreas.

https://science.sciencemag.org/content/sci/209/4458/823.full.pdf

Vitamin D deficiency inhibits pancreatic secretion of insulin

Introduction Vitamin D is generally accepted as being essential for life in higher animals (278). It is one of the most important biological regulators of calcium and phosphorus (406) metabolism. Along with the two peptide hormones PTH and calcitonin, vitamin D is responsible for the minute-to-minute as well as the day-to-day establishment and maintenance of calcium homeostasis. The substance vitamin D, or cholecalciferol, was first identified through the nutritional studies of Sir Edward Mellanby (243), which identified rickets as a disease state resulting from a deficiency of vitamin D, as well as through the biochemical/chemical studies of McCollum and co-workers (242), who demonstrated that there was more than one fat-soluble vitamin. Together these studies established a deficiency state, namely rickets, which was attributable to the newly discovered, nutritionally important fat-soluble component, vitamin D. In retrospect, however, the most important discovery related to the appreciation by Huldschins...

The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins).

The right ovary and oviduct are present in embryonic stages of all birds, but the distribution of primordial germ cells to the ovaries of the chicken becomes asymmetrical by day 4 of incubation, and by day 10 regression of the right oviduct begins. The reproductive system of birds (Galliformes) consists of a single left ovary and its oviduct, although on occasion a functional right ovary and oviduct may be present. Among the falconiformes and in the brown kiwi, both left and right gonads and associated oviducts are commonly functional, although the ovaries may be asymmetrical in size; in sparrows and pigeons, about 5% of specimens have two developed ovaries (see Romanoff and Romanoff, 1949; Kinsky, 1971).

R.H. Wasserman

Papers

Vitamin D-dependent calcium-binding protein. Purification and some properties.

Vitamin D3-induced calcium-binding protein: Partial purification, electrophoretic visualization, and tissue distribution

Vitamin D3 induction of a calcium-binding protein in the uterus of the laying hen

Vitamin D3-induced Calcium-binding Protein: BINDING CHARACTERISTICS, CONFORMATIONAL EFFECTS, AND OTHER PROPERTIES

Actinomycin D inhibition of vitamin D3-induced calcium-binding protein (CaBP) formation in chick duodenal mucosa