Type II Hyperlipoproteinemia159, 192 193 194 195 196 General Definitions By the Type II lipoprotein pattern we mean an increase in the concentration of lipoproteins that have discrete β mobility b

Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease.

Animal lipoproteins: chemistry, structure, and comparative aspects.

[54] Thin-layer chromatography of lipids

1. The lipid compositions of the low-density lipoproteins, the high-density lipoproteins and the ultracentrifugal residue of human serum are presented, with emphasis on certain lipoprotein classes and lipid components not previously described. 2. Except for the lipoproteins with the lowest and highest densities, there is a trend for stepwise successive increase or, respectively, decrease in the relative amounts of the main constituents of lipoproteins. 3. High-density lipoprotein-2 and high-density lipoprotein-3 have different amounts of certain lipids; high-density lipoprotein-2 has relatively more free cholesterol and sphingomyelin; high-density lipoprotein-3 has more free fatty acids, diglycerides and ceramide monohexosides. 4. All the lipoproteins contain hydrocarbons of the alkane series. The greatest amount, which averages 4.4% of total lipid extracted, is in the ultracentrifugal residue; n-alkanes comprise 18-50% of the hydrocarbons. 5. All the lipoproteins contain ceramide monohexosides. The highest relative contents of these glycolipids are in high-density lipoprotein-3 and in the ultracentrifugal residue. 6. The ultracentrifugal residue contains 55% of the total quantity of free fatty acids present in serum. The remaining free fatty acids are distributed among the other lipoprotein classes. 7. The choline-containing phospholipids (phosphatidylcholine, lysophosphatidylcholine and sphingomyelin) comprise about 90% of the phospholipids in all the lipoprotein classes except the low-density lipoprotein-2, which contains about 80% of these phospholipids. 8. The presence of a large amount of lysophosphatidylcholine in the ultracentrifugal residue and the successive decrease of sphingomyelin from the low-density lipoprotein-1 to the ultracentrifugal residue was confirmed. 9. The low-density lipoprotein-2 and the ultracentrifugal residue are characterized by relatively high contents of the lower glycerides.

/pdf/lipid-composition-of-human-serum-lipoproteins-1qngvn41l0.pdf

Lipid composition of human serum lipoproteins

Pyrimidine nucleosidases. their classification and relationship to uric acid ribonucleoside phosphorylase.

1. Lipoproteins were measured in sera from 11 young women having a similar environment and diet. Sera were obtained at weekly intervals over a 12-week period. The values of the lipoproteins during periods in the normal ovulatory cycle were compared to assess their relation to reported hormone concentrations in blood. 2. Only the 4-0s(f) (HDL(2)) (d 1.125 sodium chloride) fraction changed significantly; it increased at ovulation in ten of the 11 subjects and fell as menstruation approached. 3. There was greater variability in most of the low-density rather than the high-density lipoproteins within individuals. The lipoprotein class most characteristic for an individual was the 4-0s(f) or HDL(2) fraction.

/pdf/fluctuations-in-human-serum-lipoproteins-during-the-normal-112xb7qgw5.pdf

Fluctuations in human serum lipoproteins during the normal menstrual cycle.

AN extensive literature is available dealing with the comparison of serum lipoprotein and lipid concentrations between men and women1,2. The present concept is that normal pre-menopausal women have greater amounts of high-density (or α-) lipoproteins than men of a comparable age. This difference has been ascribed to sex hormone secretion, especially higher œstrogen-levels in women.

High-density lipoprotein concentrations in men and women.

Three high-denisity lipoprotein classes and one protein were separated from rat-liver plasma in membranes that had been treated with mild sonic oscillation. The lipoproteinis were separated and identified by techniques in which ultracentrifugation was used. Enzyme markers and electron-microscopic examination revealed membrane preparations essentially free of contaminating cellular partictulates.

https://science.sciencemag.org/content/sci/156/3775/665.full.pdf

R.K. Barclay

Papers

Lipid composition of human serum lipoproteins

Pyrimidine nucleosidases. their classification and relationship to uric acid ribonucleoside phosphorylase.

Fluctuations in human serum lipoproteins during the normal menstrual cycle.

High-density lipoprotein concentrations in men and women.

Plasma membranes of rat liver: isolation of lipoprotein macromolecules.