Rachna Rath

TL;DR: The potential role of B cl-2 antiapoptotic proteins in the development of cancer chemoresistance is overviewed and the clinical approaches that use Bcl-2 inhibitors to restore cell death in chemoresistant and recurrent tumors are overviewed.

TL;DR: This work uncovers a critical function of DDX3 and provides a new role in m6 demethylation of RNA and a combination regimen of ketorolac salt with cisplatin deserves further clinical investigation in advanced OSCC.

TL;DR: In patient-derived xenograft model of advanced stage and chemoresistant OSCC tumor, Triptolide restores cisplatin-mediated cell death and facilitates significant reduction of tumor burdens.

TL;DR: In this paper, CMTM6 has been identified as a stabilizer of programmed cell death ligand 1, leading to activation of Wnt signaling mediated by AKT-glycogen synthase kinase-3β.

TL;DR: In this article, RNA sequencing and global proteomic profiling of human OSCC lines presenting with sensitive, early and late cisplatin-resistance patterns were performed to identify the causative factors of chemoresistance.