R
Radboud J E M Dolhain
Researcher at Erasmus University Rotterdam
Publications - 109
Citations - 5236
Radboud J E M Dolhain is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Pregnancy & Rheumatoid arthritis. The author has an hindex of 29, co-authored 96 publications receiving 4356 citations. Previous affiliations of Radboud J E M Dolhain include Erasmus University Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
The EULAR Points to Consider for Use of Antirheumatic Drugs Before Pregnancy, and During Pregnancy and Lactation
Carina Götestam Skorpen,Maria Hoeltzenbein,Angela Tincani,Rebecca Fischer-Betz,Elisabeth Elefant,Christina D. Chambers,José António P. Da Silva,Catherine Nelson-Piercy,Irene Cetin,Nathalie Costedoat-Chalumeau,Radboud J E M Dolhain,Frauke Förger,Munther A. Khamashta,Guillermo Ruiz-Irastorza,Angela Zink,Jiri Vencovsky,Maurizio Cutolo,N. Caeyers,Claudia Zumbühl,Monika Østensen +19 more
TL;DR: Compatibility with pregnancy and lactation was found for antimalarials, sulfasalazine, azathioprine, ciclosporin, tacrolimus, colchicine, intravenous immunoglobulin and glucocorticoids, and tumour necrosis factor inhibitors.
Journal ArticleDOI
Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study.
Yaël A de Man,Radboud J E M Dolhain,Fleur E. van de Geijn,Sten P. Willemsen,Johanna M. W. Hazes +4 more
TL;DR: It is demonstrated that patients with rheumatoid arthritis achieve remission during pregnancy and deteriorate postpartum, although less frequently than previously described.
Journal ArticleDOI
Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.
J. P. van Hamburg,Patrick S. Asmawidjaja,Nadine Davelaar,Anne-Marie Mus,E. M. Colin,J. M. W. Hazes,Radboud J E M Dolhain,Erik Lubberts +7 more
TL;DR: Th17 cells, but not Th1 cells, cooperated with RASFs in a proinflammatory feedback loop, revealing a potential mechanism by which human Th17 cells drive chronic destructive disease in patients with RA.
Journal ArticleDOI
Association of higher rheumatoid arthritis disease activity during pregnancy with lower birth weight: Results of a national prospective study
Yaël A de Man,Johanna M. W. Hazes,Hugo van der Heide,Sten P. Willemsen,Christianne J.M. de Groot,Eric A.P. Steegers,Radboud J E M Dolhain +6 more
TL;DR: Pregnancy outcome in women with well-controlled RA is comparable with that in the general population, and the effect of prednisone on birth weight is mediated by a lower gestational age at delivery, whereas a higher level of disease activity independently influences birth weight negatively, suggesting an immune-mediated mechanism.
Journal ArticleDOI
Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum
Manfred Wuhrer,Jord C. Stam,Jord C. Stam,Fleur E. van de Geijn,Carolien A. M. Koeleman,C. Theo Verrips,Radboud J E M Dolhain,Cornelis H. Hokke,André M. Deelder +8 more
TL;DR: A robust method for the isolation of IgG subclasses using protein A (binds IgG1, IgG2, and IgG4) and protein G ( binds additionally IgG3) at the 96‐well plate level, which is suitable for automation is described and revealed distinct differences in N‐glycosylation between the four IgGSubclasses.