R
Radhika A. Vaishnav
Researcher at University of Louisville
Publications - 27
Citations - 1682
Radhika A. Vaishnav is an academic researcher from University of Louisville. The author has contributed to research in topics: Oxidative stress & Olfactory epithelium. The author has an hindex of 13, co-authored 22 publications receiving 1545 citations. Previous affiliations of Radhika A. Vaishnav include Loyola University Chicago & University of Kentucky.
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Journal ArticleDOI
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.
Sanne Weijzen,Paola Rizzo,Mike Braid,Radhika A. Vaishnav,Suzanne M. Jonkheer,Andrei Zlobin,Barbara A. Osborne,Sridevi Gottipati,Jon C. Aster,William C. Hahn,William C. Hahn,Michael P. Rudolf,Kalliopi P. Siziopikou,W. Martin Kast,Lucio Miele +14 more
TL;DR: It is shown that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo and suggests that it might be a novel therapeutic target.
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Antioxidant therapies for traumatic brain injury.
TL;DR: It is proposed that the most effective approach to interrupt posttraumatic oxidative brain damage after TBI might involve the combined treatment with mechanistically complementary antioxidants that simultaneously scavenge LP-initiating free radicals, inhibit LP propagation, and lastly remove neurotoxic LP byproducts.
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The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease.
Animesh Alexander Raha,Radhika A. Vaishnav,Robert P. Friedland,Adrian Bomford,Ruma Raha-Chowdhury +4 more
TL;DR: The results suggest that the reduction in ferroportin levels are likely associated with cerebral ischaemia, inflammation, the loss of neurons due to the well-characterised protein misfolding, senile plaque formation and possibly the ageing process itself.
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Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice.
TL;DR: Several of the up-regulated and oxidized proteins in the brains of old mice identified in this report are known to be oxidized in neurodegenerative diseases as well, suggesting that these proteins may be particularly susceptible to processes associated with neurodegenersation.
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Lipid peroxidation-derived reactive aldehydes directly and differentially impair spinal cord and brain mitochondrial function.
TL;DR: The results of this study show that 4-hydroxy-2-nonenal and acrolein can directly and differentially impair spinal cord and brain mitochondrial function, and that the targets for the toxic effects of aldehydes appear to include pyruvate dehydrogenase and complex I-associated proteins.