Michael P. Rudolf

TL;DR: It is shown that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo and suggests that it might be a novel therapeutic target.

TL;DR: It is demonstrated that immature human DCs are fully activated by chimeric HPV-16 VLPs and subsequently are capable of inducing endogenously processed epitope-specific human T cell responses in vitro, which could explain the high immunogenicity and efficiency of VLps as vaccines.

TL;DR: The interaction of human papillomavirus with Langerhans cells, which would be the first APCs the virus comes into contact with during infection, is explored and it is determined that dendritic cells, normally targeted by vaccination procedures and Langers cells, Normally targeted by the natural virus equally internalize human papilomav virus-like particles.

TL;DR: Various candidate HPV vaccines are being developed and tested in animal models and/or in human clinical trials, and these HPV vaccines, both preventive and therapeutic, are the subjects of this review.

TL;DR: The binding affinities for all possible 9-mer peptides spanning the entire E6 and E7 amino acid sequence are determined, establishing the binding peptides as potential cytotoxic T-cell epitopes for HLA-A*0201.