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Radim Strnadel
Publications - 7
Citations - 232
Radim Strnadel is an academic researcher. The author has contributed to research in topics: Treponema & Genome. The author has an hindex of 6, co-authored 7 publications receiving 187 citations.
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Journal ArticleDOI
Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance
Linda Grillová,Helena Pětrošová,Lenka Mikalová,Radim Strnadel,Eliška Dastychová,Ivana Kuklová,Martina Kojanová,Miluše Kreidlová,Daniela Vaňousová,Jana Hercogová,Přemysl Procházka,Hana Zákoucká,Alena Krchňáková,Vladimír Vašků,David Šmajs +14 more
TL;DR: The number of genotypes detected among syphilis patients in a particular year increased to six in both 2012 and 2013, although they were not the same six.
Journal ArticleDOI
Sequencing-based molecular typing of treponema pallidum strains in the Czech Republic: all identified genotypes are related to the sequence of the SS14 strain.
Magdalena Flasarová,Petra Pospíšilová,Lenka Mikalová,Zuzana Vališová,Eliška Dastychová,Radim Strnadel,Ivana Kuklová,Vladana Woznicová,Hana Zákoucká,David Šmajs +9 more
TL;DR: A set of 415 clinical samples isolated from 294 patients suspected of having syphilis collected in the Czech Republic between 2004 and 2010 was tested for the presence of treponemal DNA, and variants of arp and tpr genes appear to combine independently with sequence variants of TP0136, TP0548 and 23S rRNA genes.
Journal ArticleDOI
Syphilis-causing strains belong to separate SS14-like or Nichols-like groups as defined by multilocus analysis of 19 Treponema pallidum strains
Lukáš Nechvátal,Helena Pětrošová,Linda Grillová,Petra Pospíšilová,Lenka Mikalová,Radim Strnadel,Ivana Kuklová,Martina Kojanová,Miluše Kreidlová,Daniela Vaňousová,Přemysl Procházka,Hana Zákoucká,Alena Krchňáková,David Šmajs +13 more
TL;DR: Assessment of syphilitic isolates in the Czech Republic revealed that clinical isolates follow the SS14- and Nichols-like distribution, and TP0558 was shown as the only tested locus that evolved under negative selection within TPA strains.
Journal ArticleDOI
Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens.
Linda Grillová,Linda Grillová,Jan Oppelt,Lenka Mikalová,Markéta Nováková,LLorenzo Giacani,Anežka Niesnerová,Angel A. Noda,Ariel E. Mechaly,Petra Pospíšilová,Darina Čejková,Philippe Grange,Nicolas Dupin,Radim Strnadel,Marcus Y Chen,Ian Denham,Natasha Arora,Mathieu Picardeau,Christopher Weston,R. Allyn Forsyth,David Šmajs +20 more
TL;DR: The existence of strains with different repertoires of surface-exposed antigens circulating in the current human population is revealed, which should be taken into account during syphilis vaccine development.
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A retrospective study on nested PCR detection of syphilis treponemes in clinical samples: PCR detection contributes to the diagnosis of syphilis in patients with seronegative and serodiscrepant results
Eliška Vrbová,Lenka Mikalová,Linda Grillová,Petra Pospíšilová,Radim Strnadel,Eliška Dastychová,Martina Kojanová,Miluše Kreidlová,Daniela Vaňousová,Filip Rob,Přemysl Procházka,Alena Krchňáková,Vladimír Vašků,Vladana Woznicová,Monika Dvořáková Heroldová,Ivana Kuklová,Hana Zákoucká,David Šmajs +17 more
TL;DR: The nested PCR can improve diagnostics of syphilis, especially in seronegative patients and in patients with discrepant serology, as shown here.