R
Radoslaw Rola
Researcher at Medical University of Lublin
Publications - 70
Citations - 4270
Radoslaw Rola is an academic researcher from Medical University of Lublin. The author has contributed to research in topics: Neurogenesis & Subgranular zone. The author has an hindex of 25, co-authored 62 publications receiving 3844 citations. Previous affiliations of Radoslaw Rola include University of California, San Francisco & San Francisco General Hospital.
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Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Journal Article
Extreme Sensitivity of Adult Neurogenesis to Low Doses of X-Irradiation
Shinichiro Mizumatsu,Michelle Monje,Duncan R. Morhardt,Radoslaw Rola,Theo D. Palmer,John R. Fike +5 more
TL;DR: The data suggest that precursor cell radiation response and altered neurogenesis may play a contributory if not causative role in radiation-induced cognitive impairment.
Journal ArticleDOI
Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis.
Jacob Raber,Radoslaw Rola,Anthony LeFevour,Duncan R. Morhardt,Justine Curley,Shinichiro Mizumatsu,Scott R. VandenBerg,John R. Fike +7 more
TL;DR: It is shown that the Barnes maze is particularly sensitive for the detection of radiation-induced cognitive deficits in young adult mice and the significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation -induced cognitive impairments.
Journal ArticleDOI
Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity to Cell Cycle Checkpoints, Apoptosis and Oxidative Stress
TL;DR: The temporal coincidence between in vitro and in vivo measurements of apoptosis suggests that oxidative stress may provide a mechanistic explanation for radiation-induced inhibition of neurogenesis in the development of cognitive impairment.
Journal ArticleDOI
Alterations in hippocampal neurogenesis following traumatic brain injury in mice
Radoslaw Rola,Shinichiro Mizumatsu,Shinji Otsuka,Duncan R. Morhardt,Linda J. Noble-Haeusslein,Kelly Fishman,Matthew B. Potts,John R. Fike +7 more
TL;DR: The effects of unilateral controlled cortical impact on neurogenic cell populations in the SGZ in 2-month-old male C57BL6 mice are assessed and it is demonstrated that TBI alters both neurogenesis and gliogenesis.