M
Michelle Monje
Researcher at Stanford University
Publications - 190
Citations - 21551
Michelle Monje is an academic researcher from Stanford University. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 49, co-authored 135 publications receiving 14895 citations. Previous affiliations of Michelle Monje include Lucile Packard Children's Hospital & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
TL;DR: It is shown that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neuroGenesis after endotoxin-induced inflammation and augments neurogenescence after cranial irradiation.
Journal ArticleDOI
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel,Julie Laffy,Mariella G. Filbin,Toshiro Hara,Marni E. Shore,Marni E. Shore,Gilbert J. Rahme,Gilbert J. Rahme,Alyssa R. Richman,Alyssa R. Richman,Dana Silverbush,Dana Silverbush,McKenzie Shaw,Christine M. Hebert,Christine M. Hebert,John M. DeWitt,John M. DeWitt,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Elizabeth M. Perez,L. Nicolas Gonzalez Castro,Xiaoyang Lan,Xiaoyang Lan,Nicholas Druck,Christopher Rodman,Danielle Dionne,Alexander Kaplan,Mia Bertalan,Julia L. Small,Kristine Pelton,Sarah Becker,Dennis M. Bonal,Quang-Dé Nguyen,Rachel L. Servis,Jeremy M. Fung,Ravindra Mylvaganam,Lisa Mayr,Johannes Gojo,Christine Haberler,René Geyeregger,Thomas Czech,Irene Slavc,Brian V. Nahed,William T. Curry,Bob S. Carter,Hiroaki Wakimoto,Priscilla K. Brastianos,Tracy T. Batchelor,Anat Stemmer-Rachamimov,Maria Martinez-Lage,Matthew P. Frosch,Ivan Stamenkovic,Nicolo Riggi,Esther Rheinbay,Esther Rheinbay,Michelle Monje,Orit Rozenblatt-Rosen,Daniel P. Cahill,Anoop P. Patel,Tony Hunter,Inder M. Verma,Keith L. Ligon,Keith L. Ligon,David N. Louis,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Itay Tirosh,Mario L. Suvà,Mario L. Suvà +71 more
TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.
Journal ArticleDOI
Irradiation induces neural precursor-cell dysfunction
TL;DR: It is shown that the deficit in neurogenesis reflects alterations in the microenvironment that regulates progenitor-cell fate, as well as a defect in the proliferative capacity of the neural progenitors in the irradiated hippocampus.
Journal ArticleDOI
Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain
Erin M. Gibson,David Purger,Christopher Mount,Andrea K. Goldstein,Grant L. Lin,Lauren Wood,Ingrid Inema,Sarah E. Miller,Gregor Bieri,J. Bradley Zuchero,Ben A. Barres,Pamelyn Woo,Hannes Vogel,Michelle Monje +13 more
TL;DR: In vivo optogenetic techniques in awake, behaving mice are used to provide direct evidence that neuronal activity regulates changes in myelin-forming cells within an active circuit, suggesting that adaptive changes inMyelin-form cells represent a type of behaviorally relevant neural plasticity.
Journal ArticleDOI
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Itay Tirosh,Andrew S. Venteicher,Andrew S. Venteicher,Christine Hebert,Christine Hebert,Leah E. Escalante,Leah E. Escalante,Anoop P. Patel,Keren Yizhak,Keren Yizhak,Jonathan M. Fisher,Christopher Rodman,Christopher Mount,Mariella G. Filbin,Mariella G. Filbin,Cyril Neftel,Cyril Neftel,Niyati Desai,Jackson Nyman,Benjamin Izar,Christina C. Luo,Joshua M. Francis,Joshua M. Francis,Aanand A. Patel,Maristela L. Onozato,Nicolo Riggi,Kenneth J. Livak,David Gennert,Rahul Satija,Brian V. Nahed,William T. Curry,Robert L. Martuza,Ravindra Mylvaganam,A. John Iafrate,Matthew P. Frosch,Todd R. Golub,Todd R. Golub,Todd R. Golub,Miguel Rivera,Miguel Rivera,Gad Getz,Gad Getz,Orit Rozenblatt-Rosen,Daniel P. Cahill,Michelle Monje,Bradley E. Bernstein,Bradley E. Bernstein,David N. Louis,Aviv Regev,Aviv Regev,Mario L. Suvà,Mario L. Suvà +51 more
TL;DR: In this paper, the authors profile 4,347 single cells from six IDH1 or IDH2 mutant human oligodendrogliomas by RNA sequencing and reconstruct their developmental programs from genome-wide expression signatures.