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Radost Vatcheva
Researcher at Lincoln's Inn
Publications - 6
Citations - 249
Radost Vatcheva is an academic researcher from Lincoln's Inn. The author has contributed to research in topics: Yeast artificial chromosome & Chromosome 21. The author has an hindex of 6, co-authored 6 publications receiving 248 citations.
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Journal ArticleDOI
An integrated YAC-overlap and ‘cosmid-pocket’ map of the human chromosome 21
Dean Nižetić,Lisa Gellen,Renata M.J. Hamvas,Richard Mott,Andrei Grigorlev,Radost Vatcheva,Günther Zehetner,Marie-Laure Yaspo,Annie Dutriaux,Carmela Lopes,Jean-M. Delabar,Christine Van Broeckhoven,Marie-Claude Potler,Hans Lehrach +13 more
TL;DR: This map provides immediately available low-complexity cosmid material for high resolution FISH mapping of chromosomal aberrations on interphase nuclei, and for rapid positional isolation of transcripts in the highly resolved regions of genetic interest.
Journal ArticleDOI
Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximately 90 kb upstream of this gene.
R.H. Flomen,Radost Vatcheva,Patricia Gorman,Pedro R. Baptista,Juergen Groet,Ingeborg Barišić,Ivo Ligutić,Dean Nižetić +7 more
TL;DR: It is demonstrated that the 4q25 linked RIEG disorder can arise from the haploid, whole-gene deletion of RIEG, but also from a translocation break 90 kb upstream from the gene.
Journal ArticleDOI
Chromosomal assignment of human YAC clones by fluorescence in situ hybridization: use of single-yeast-colony PCR and multiple labeling.
Antonio Baldini,Mark T. Ross,Dean Nizetic,Radost Vatcheva,Elizabeth A. Lindsay,Hans Lehrach,Marcello Siniscalco +6 more
TL;DR: The application of Alu-PCR to single-yeast colonies permits the mapping of YACs at a very early stage of their characterization and the application of multicolor hybridization techniques to increase the potential of the method.
Journal ArticleDOI
Selection of a human chromosome 21 enriched YAC sub-library using a chromosome-specific composite probe
Mark T. Ross,D Nizetíc,C Nguyen,C J Knights,Radost Vatcheva,N Burden,C Douglas,Günther Zehetner,David C. Ward,Antonio Baldini +9 more
TL;DR: The isolation of 388 YAC clones from a human library is reported by the hybridization of a composite chromosome 21 probe to a high–density array of YAC clone collections, representing a twofold coverage of the chromosome.
Journal ArticleDOI
An integrated YAC map of the human X chromosome.
H. Roest Crollius,Mark T. Ross,Andrei Grigoriev,Andrei Grigoriev,C J Knights,E. Holloway,J Misfud,Kim K.C. Li,M Playford,Simon G. Gregory,Sean Humphray,Alison J. Coffey,C G See,S Marsh,Radost Vatcheva,J. Kumlien,T. Labella,V Lam,K H Rak,K Todd,Richard Mott,D Graeser,Gudrun A. Rappold,Günther Zehetner,Annemarie Poustka,Hans Lehrach +25 more
TL;DR: A YAC contig map of the X chromosome covering 125 Mb of DNA in 25 contigs and containing 906 YAC clones is constructed, which exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps.