R
Rafael Oriol
Researcher at French Institute of Health and Medical Research
Publications - 190
Citations - 9065
Rafael Oriol is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 52, co-authored 190 publications receiving 8833 citations. Previous affiliations of Rafael Oriol include Centre national de la recherche scientifique & University of Paris.
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Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation.
TL;DR: The localization of this linear-B epitope on vascular endothelium and its reactivity with natural human anti-aGal antibodies suggest that it may play a major role in the hyperacute vascular rejection of pig to man organ xenografts.
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Genetics of ABO, H, Lewis, X and related antigens.
TL;DR: The phylogeny of ABH determinants shows that they appeared as tissular antigens much earlier than as red cellAntigens, and an effort is made to correlate their tissular distribution in the adult with the embryological origin of each tissue.
Journal ArticleDOI
Identification of α-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man
David K. C. Cooper,A.H. Good,Eugen Koren,Rafael Oriol,A.J. Malcolm,R.M. Ippolito,F. A. Neethling,Y. Ye,Egidio Romano,N. Zuhdi +9 more
TL;DR: The results suggest that human anti-pig antibodies are mainly directed against alpha-galactosyl structures, andExtracorporeal immunoadsorption of human plasma through columns of the specific synthetic carbohydrate(s) might lead to depletion of anti-Pig antibodies and allow discordant xenografting in man.
Journal ArticleDOI
The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.
TL;DR: The animal sialyltransferases are Golgi type II transmembrane glycosyl transferases that catalyze transfer of sialic acid from CMP-Neu5Ac to the glycan moiety of glycoconjugates as discussed by the authors.
Journal ArticleDOI
Oligosaccharides and Discordant Xenotransplantation
TL;DR: It is concluded that the alpha Gal epitope is either monomorphic or at least has a high incidence in porcine species, since it seems unlikely that either of these epitopes plays a role in the vascular rejection that takes place when pig organs are transplanted into primates.