R
Raffaele Manna
Researcher at Catholic University of the Sacred Heart
Publications - 208
Citations - 3965
Raffaele Manna is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Familial Mediterranean fever & Insulin. The author has an hindex of 32, co-authored 192 publications receiving 3510 citations. Previous affiliations of Raffaele Manna include Agostino Gemelli University Polyclinic & Sapienza University of Rome.
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Journal ArticleDOI
Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes.
Ebun Aganna,L. J. Hammond,Philip N. Hawkins,Anna Aldea,Shane McKee,Hans Kristian Ploos van Amstel,Claudia Mischung,Koichi Kusuhara,Frank T. Saulsbury,Helen J. Lachmann,Alison Bybee,Elizabeth M. McDermott,Micaela La Regina,Juan I. Aróstegui,Josep M. Campistol,Sharron Worthington,Kevin P. High,Michael G. Molloy,Nicholas Baker,Jeff L. Bidwell,José L. Castañer,Margo Whiteford,P. L. Janssens-Korpola,Raffaele Manna,Richard J. Powell,Patricia Woo,Pilar Solis,Kirsten Minden,Joost Frenkel,Jordi Yagüe,R. Mirakian,Graham A. Hitman,Michael F. McDermott +32 more
TL;DR: The presence of TNFRSF1A shedding defects and low sTNFRSf1A levels in 3 families without a TNFRN1A mutation indicates that the genetic basis among patients with "TRAPS-like" features is heterogeneous.
Journal ArticleDOI
Management and treatment of lactose malabsorption.
Massimo Montalto,Valentina Curigliano,Luca Santoro,Monica Vastola,Giovanni Cammarota,Raffaele Manna,Antonio Gasbarrini,Giovanni Gasbarrini +7 more
TL;DR: The usefulness of exogenous beta-galactosidase, yogurt and probiotics for their bacterial lactase activity, pharmacological and non pharmacological strategies that can prolong contact time between enzyme and substrate delaying gastrointestinal transit time, and chronic lactose ingestion to enhance colonic adaptation are discussed.
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Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update.
TL;DR: Familial Mediterranean Fever (FMF), an autosomal recessive disorder, is characterised by recurrent attacks of fever and serositis, lasting 24-72 hours, and today the design of colchicine analogues which may have lesser toxicities and a larger therapeutic window are being worked in.
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Probiotic treatment increases salivary counts of lactobacilli: a double-blind, randomized, controlled study.
Massimo Montalto,Monica Vastola,L. Marigo,Marcello Covino,R. Graziosetto,Valentina Curigliano,Luca Santoro,Lucio Cuoco,Raffaele Manna,G. Gasbarrini +9 more
TL;DR: The increased salivary counts of lactobacilli may indicate the need to closely monitor the dental health of patients undergoing long-term probiotics treatment, even when this treatment is administrated in a form that avoids direct contact with the oral cavity.
Journal ArticleDOI
Familial Mediterranean fever is no longer a rare disease in Italy
Micaela La Regina,Gabriella Nucera,M Diaco,Antonio Domenico Procopio,Giovanni Gasbarrini,Cécile Notarnicola,Isabelle Koné-Paut,Isabelle Touitou,Raffaele Manna +8 more
TL;DR: Italian FMF patients, 40 women and 31 men, aged from 3 to 75 years, have shown all the clinical manifestations indicative of FMF described in the literature, but with a lower incidence of amyloidosis.