J
Juan I. Aróstegui
Researcher at University of Barcelona
Publications - 163
Citations - 8372
Juan I. Aróstegui is an academic researcher from University of Barcelona. The author has contributed to research in topics: Blau syndrome & Multiple myeloma. The author has an hindex of 41, co-authored 147 publications receiving 7000 citations. Previous affiliations of Juan I. Aróstegui include Hospital General Universitario Gregorio Marañón.
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Journal ArticleDOI
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
Horst von Bernuth,Capucine Picard,Capucine Picard,Zhongbo Jin,Rungnapa Pankla,Rungnapa Pankla,Hui Xiao,Cheng-Lung Ku,Cheng-Lung Ku,Maya Chrabieh,Maya Chrabieh,Imen Ben Mustapha,Imen Ben Mustapha,Imen Ben Mustapha,Pegah Ghandil,Pegah Ghandil,Yildiz Camcioglu,Júlia Vasconcelos,Nicolas Sirvent,Margarida Guedes,Artur Bonito Vitor,María José Herrero-Mata,Juan I. Aróstegui,Carlos Rodrigo,Laia Alsina,Estibaliz Ruiz-Ortiz,Manel Juan,Claudia Fortuny,Jordi Yagüe,Jordi Anton,Mariona Pascal,Huey Hsuan Chang,Lucile Janniere,Lucile Janniere,Yoann Rose,Yoann Rose,Ben Zion Garty,Helen Chapel,Andrew C. Issekutz,László Maródi,Carlos Rodríguez-Gallego,Jacques Banchereau,Laurent Abel,Laurent Abel,Xiaoxia Li,Damien Chaussabel,Anne Puel,Anne Puel,Jean-Laurent Casanova,Jean-Laurent Casanova +49 more
TL;DR: Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, but these patients were otherwise healthy, with normal resistance to other microbes.
Journal ArticleDOI
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Alberto Baroja-Mazo,Fátima Martín-Sánchez,Ana I. Gomez,Carlos Martinez,Joaquín Amores-Iniesta,Vincent Compan,Maria Barberà-Cremades,Jordi Yagüe,Estibaliz Ruiz-Ortiz,Jordi Anton,Segundo Buján,Isabelle Couillin,David Brough,Juan I. Aróstegui,Pablo Pelegrín +14 more
TL;DR: These findings support a model whereby the NLRP3 inflammasome, acting as an extracellular oligomeric complex, amplifies the inflammatory response.
Journal ArticleDOI
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga,Montserrat Cols,Carolina M. Barra,Bing-Yang He,Linda Cassis,Maurizio Gentile,Laura Comerma,Alejo Chorny,Meimei Shan,Weifeng Xu,Giuliana Magri,Daniel M. Knowles,Wayne Tam,April Chiu,James B. Bussel,Sergi Serrano,José Antonio Lorente,Beatriz Bellosillo,Josep Lloreta,Nuria Juanpere,Francesc Alameda,Teresa Baró,Cristina Díaz de Heredia,Nuria Toran,Albert Català,Montserrat Torrebadell,Claudia Fortuny,Victoria Cusí,Carmen Carreras,George A. Diaz,J. Magarian Blander,Claire-Michèle Farber,Guido Silvestri,Charlotte Cunningham-Rundles,Michaela Calvillo,Carlo Dufour,Lucia Dora Notarangelo,Vassilios Lougaris,Alessandro Plebani,Jean-Laurent Casanova,Stephanie C. Ganal,Andreas Diefenbach,Juan I. Aróstegui,Manel Juan,Jordi Yagüe,Nizar Mahlaoui,Jean Donadieu,Kang Chen,Andrea Cerutti +48 more
TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.
Journal ArticleDOI
Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
Capucine Picard,Capucine Picard,Horst von Bernuth,Horst von Bernuth,Horst von Bernuth,Pegah Ghandil,Pegah Ghandil,Pegah Ghandil,Maya Chrabieh,Maya Chrabieh,Ofer Levy,Peter D. Arkwright,Douglas R. McDonald,Raif S. Geha,Hidetoshi Takada,Jens C. Krause,C. Buddy Creech,Cheng-Lung Ku,Cheng-Lung Ku,Stephan Ehl,László Maródi,Saleh Al-Muhsen,Saleh Al-Muhsen,Sami Al-Hajjar,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,Abdulaziz Al-Ghonaium,Noorbibi K. Day-Good,Steven M. Holland,John I. Gallin,Helen Chapel,David P. Speert,Carlos Rodríguez-Gallego,Elena Colino,Ben Zion Garty,Chaim M. Roifman,Toshiro Hara,Hideto Yoshikawa,Shigeaki Nonoyama,Joseph B. Domachowske,Andrew C. Issekutz,Mimi L.K. Tang,Joanne Smart,Simona Eva Zitnik,Cyrille Hoarau,Dinakantha S. Kumararatne,Adrian J. Thrasher,E. Graham Davies,Claire Bethune,Nicolas Sirvent,Dominique De Ricaud,Yildiz Camcioglu,Júlia Vasconcelos,Margarida Guedes,Artur Bonito Vitor,Carlos Rodrigo,Francisco Almazán,Maria Méndez,Juan I. Aróstegui,Laia Alsina,Claudia Fortuny,Janine Reichenbach,James W. Verbsky,Xavier Bossuyt,Rainer Döffinger,Laurent Abel,Laurent Abel,Anne Puel,Anne Puel,Jean-Laurent Casanova +69 more
TL;DR: IRAK-4 and MyD88 deficiencies predispose patients to recurrent life-threatening bacterial diseases, such as invasive pneumococcal disease in particular, in infancy and early childhood, with weak signs of inflammation.
Journal ArticleDOI
Classification criteria for autoinflammatory recurrent fevers
Marco Gattorno,Michael Hofer,Silvia Federici,Federica Vanoni,Francesca Bovis,Ivona Aksentijevich,Jordi Anton,Juan I. Aróstegui,Karyl S. Barron,Eldad Ben-Cherit,Paul A. Brogan,Luca Cantarini,Isabella Ceccherini,Fabrizio De Benedetti,Fatma Dedeoglu,Erkan Demirkaya,Joost Frenkel,Raphaela Goldbach-Mansky,Ahmet Gül,Véronique Hentgen,Hal M. Hoffman,Tilmann Kallinich,Isabelle Koné-Paut,Jasmin B Kuemmerle-Deschner,Helen J. Lachmann,Ronald M. Laxer,Avi Livneh,Laura Obici,Seza Ozen,Dorota Rowczenio,Ricardo Russo,Yael Shinar,Anna Simon,Nataša Toplak,Isabelle Touitou,Yosef Uziel,Marielle E. van Gijn,Dirk Foell,Claudia Garassino,DL Kastner,Alberto Martini,Maria Pia Sormani,Nicolino Ruperto +42 more
TL;DR: Eurofever proposes a novel set of validated classification criteria for HRF and PFAPA with high sensitivity and specificity and shows a high accuracy in an independent data set of 1018 patients.