R
Raffaella Ghittoni
Researcher at University of Siena
Publications - 20
Citations - 1430
Raffaella Ghittoni is an academic researcher from University of Siena. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 14, co-authored 20 publications receiving 1320 citations. Previous affiliations of Raffaella Ghittoni include International Agency for Research on Cancer & University of Arizona.
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Journal ArticleDOI
T lymphocytes as targets of statins: molecular mechanisms and therapeutic perspectives.
TL;DR: Recent findings, which document an inhibitory activity of statins on T-cell activation, proliferation, differentiation to Th1 cells and migration across the blood-brain barrier, are reviewed.
Journal Article
Anthrax Toxins Suppress T Lymphocyte Activation by Disrupting Antigen Receptor Signaling
Paccani,Fiorella Tonello,Raffaella Ghittoni,Mariarita Natale,Lucia Muraro,Mm D'Elios,Wj Tang,Cesare Montecucco,Ct Baldari +8 more
TL;DR: In this article, the authors identify a novel strategy of immune evasion by Bacillus anthracis, based on both effector subunits of the toxic complex, and targeted to a key cellular component of adaptive immunity.
Journal Article
Homocysteine enhances cytokine production in cultured synoviocytes from rheumatoid arthritis patients.
P.E. Lazzerini,Enrico Selvi,Sauro Lorenzini,Pier Leopoldo Capecchi,Raffaella Ghittoni,Stefania Bisogno,M Catenaccio,Renzo Marcolongo,Mauro Galeazzi,Franco Laghi-Pasini +9 more
TL;DR: Hcy enhances IL-1-dependent cytokine production by rheumatoid synoviocytes at a concentration measurable in RA joints in vivo, which may represent an important risk factor for the progression of cardiovascular diseases, but it may also contribute to the joint damage.
Journal ArticleDOI
Antigenic properties of HCMV peptides displayed by filamentous bacteriophages vs. synthetic peptides.
Cristina Ulivieri,Alessandra Citro,Federico Ivaldi,Dina Mascolo,Raffaella Ghittoni,Daniela Fanigliulo,Fabrizio Manca,Cosima T. Baldari,Giuseppina Li Pira,Giovanna Del Pozzo +9 more
TL;DR: The results show a general enhancement of T-cell responses when antigenic peptides are carried by phages, and a more robust and long lasting response of the reporter T- cell hybridoma compared to peptide stimulation.
Journal ArticleDOI
Cell-Autonomous CCL5 Transcription by Memory CD8 T Cells Is Regulated by IL-4
Antoine Marçais,Charles-Antoine Coupet,Thierry Walzer,Martine Tomkowiak,Raffaella Ghittoni,Jacqueline Marvel +5 more
TL;DR: Results indicate that the expression of CCL5 is an intrinsic property acquired by memory CD8 T cells that is regulated by environmental factors.