Rainer Puhr

TL;DR: Two simple modifications of Firth's logistic regression resulting in unbiased predicted probabilities are proposed and one introduces some bias, but this is compensated by a decrease in the mean squared error.

TL;DR: CFL is proposed as an attractive solution to the stratified analysis of binary data, irrespective of the occurrence of monotone likelihood, and confidence intervals and tests based on the penalized conditional likelihood had close-to-nominal coverage rates and yielded highest power among all methods compared, respectively.

TL;DR: The TUXEDO-1 trial as discussed by the authors showed that trastuzumab deruxtecan showed a high intracranial response rate in patients with active brain metastases from HER2-positive breast cancer and should be considered as a treatment option in this setting.

TL;DR: Demand for rabies hyperimmunoglobulin has increased recently, requiring optimization of vaccination schemes for immunized plasma donors, and any correlation of the immune response with blood group or isoantibody levels was not found.