Raïssa Nadège Caboré

TL;DR: The first prospective controlled cohort study in women and infants on the effects of using Boostrix(®), a combined tetanus, diphtheria and acellular pertussis vaccine, during pregnancy to assess possible interference with infant immune responses is reported.

TL;DR: Maternal antibodies induced by vaccination during pregnancy close the susceptibility gap for pertussis in young infants, and limited interference with the infant vaccine responses was observed.

TL;DR: The present results indicate still a minor blunting effect 1 month after a fourth vaccine dose for anti-PT antibodies, but a good humoral immune response on all measured antigens was elicited in both groups of children.

TL;DR: The present results indicate that the blunting of infant pertussis responses induced by maternal immunization, measured after a primary series of aP vaccines, was resolved with the booster aP vaccine dose.

TL;DR: A Tdap vaccination can increase vaccine specific IgG antibodies to the same extent in pregnant and in nonpregnant women, whereas the stimulation of vaccine specific Th1 type cellular immune responses with this acellular vaccine is transient and impaired during pregnancy.