R
Rajendar K. Mittapalli
Researcher at University of Minnesota
Publications - 37
Citations - 2954
Rajendar K. Mittapalli is an academic researcher from University of Minnesota. The author has contributed to research in topics: Brain metastasis & Blood–brain barrier. The author has an hindex of 24, co-authored 36 publications receiving 2572 citations. Previous affiliations of Rajendar K. Mittapalli include Texas Tech University Health Sciences Center.
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Journal ArticleDOI
Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
Paul R. Lockman,Rajendar K. Mittapalli,Kunal S Taskar,Vinay Rudraraju,Brunilde Gril,Kaci A. Bohn,Chris E. Adkins,Amanda Roberts,Helen R. Thorsheim,Julie A. Gaasch,Suyun Huang,Diane Palmieri,Patricia S. Steeg,Quentin R. Smith +13 more
TL;DR: This work shows that the BTB remains a significant impediment to standard chemotherapeutic delivery and efficacy in experimental brain metastases of breast cancer, and new brain permeable drugs will be needed.
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Orodispersible tablets: An overview
TL;DR: This review describes the various formulation aspects, disintegrants employed and technologies developed for ODTs, along with various excipients, evaluation tests, marketed formulations, and drugs explored in this field.
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Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer
Fancy Thomas,Kunal S Taskar,Vinay Rudraraju,Satyanarayana Goda,Helen R. Thorsheim,Julie A. Gaasch,Julie A. Gaasch,Rajendar K. Mittapalli,Diane Palmieri,Patricia S. Steeg,Paul R. Lockman,Quentin R. Smith +11 more
TL;DR: It is demonstrated that angiopep-2 paclitaxel conjugate shows significantly improved delivery to brain and brain metastases of breast cancer compared to free pac litaxel.
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Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma
Rajneet K. Oberoi,Karen E. Parrish,Terence T. Sio,Rajendar K. Mittapalli,William F. Elmquist,Jann N. Sarkaria +5 more
TL;DR: The influence of the blood-brain barrier on the distribution of anticancer drugs to both the tumor core and infiltrative regions of GBM is described.
Journal ArticleDOI
Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer
Kunal S Taskar,Vinay Rudraraju,Rajendar K. Mittapalli,Ramakrishna Samala,Helen R. Thorsheim,Julie A. Lockman,Brunilde Gril,Emily Hua,Diane Palmieri,Joseph W. Polli,Stephen Castellino,Stephen D. Rubin,Paul R. Lockman,Patricia S. Steeg,Quentin R. Smith +14 more
TL;DR: Results show that Lapatinib distribution to brain metastases of breast cancer is partially restricted and blood-tumor barrier permeability is a key component of lapatinib therapeutic efficacy which varies between tumors.