J
Jann N. Sarkaria
Researcher at Mayo Clinic
Publications - 360
Citations - 26469
Jann N. Sarkaria is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Temozolomide & Glioma. The author has an hindex of 64, co-authored 308 publications receiving 22678 citations. Previous affiliations of Jann N. Sarkaria include University of Minnesota & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G.W. Verhaak,Katherine A. Hoadley,Elizabeth Purdom,Victoria Wang,Yuan-yuan Qi,Matthew D. Wilkerson,C. Ryan Miller,Li Ding,Todd R. Golub,Jill P. Mesirov,Gabriele Alexe,Michael S. Lawrence,Michael O'Kelly,Pablo Tamayo,Barbara A. Weir,Stacey Gabriel,Wendy Winckler,Supriya Gupta,Lakshmi Jakkula,Heidi S. Feiler,J. Graeme Hodgson,C. David James,Jann N. Sarkaria,Cameron Brennan,Ari B. Kahn,Paul T. Spellman,Richard K. Wilson,Terence P. Speed,Terence P. Speed,Joe W. Gray,Matthew Meyerson,Gad Getz,Charles M. Perou,Charles M. Perou,D. Neil Hayes +34 more
TL;DR: A robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes is described and multidimensional genomic data is integrated to establish patterns of somatic mutations and DNA copy number.
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G.W. Verhaak,Katherine A. Hoadley,Elizabeth Purdom,Victoria Wang,Yuan-yuan Qi,Matthew D. Wilkerson,C. Ryan Miller,Li Ding,Todd R. Golub,Jill P. Mesirov,Gabriele Alexe,Michael S. Lawrence,Michael O'Kelly,Pablo Tamayo,Barbara A. Weir,Stacey Gabriel,Wendy Winckler,Supriya Gupta,Lakshmi Jakkula,Heidi S. Feiler,J. Graeme Hodgson,C. David James,Jann N. Sarkaria,Cameron Brennan,Ari B. Kahn,Paul T. Spellman,Richard K. Wilson,Terence P. Speed,Terence P. Speed,Joe W. Gray,Matthew Meyerson,Gad Getz,Charles M. Perou,Charles M. Perou,D. Neil Hayes +34 more
TL;DR: The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM) and proposed a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes as discussed by the authors.
Journal ArticleDOI
A role for ATR in the DNA damage-induced phosphorylation of p53
Randal S. Tibbetts,Kathryn M. Brumbaugh,Josie M. Williams,Jann N. Sarkaria,William A. Cliby,Sheau-Yann Shieh,Yoichi Taya,Carol Prives,Robert T. Abraham +8 more
TL;DR: Evidence that the ATM-Rad3-related protein ATR regulates phosphorylation of Ser-15 in DNA-damaged cells is provided and it is suggested that p53 is a target for phosphorylated by ATR by blocking UV-induced Ser- 15 phosphorylations in a time-independent manner.
Journal ArticleDOI
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Kui Ming Chan,Dong Fang,Haiyun Gan,Rintaro Hashizume,Chuanhe Yu,Mark A. Schroeder,Nalin Gupta,Sabine Mueller,C. David James,Robert B. Jenkins,Jann N. Sarkaria,Zhiguo Zhang +11 more
TL;DR: Results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis.
Journal Article
Inhibition of Phosphoinositide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin
Jann N. Sarkaria,Randal S. Tibbetts,Ericka C. Busby,Amy Kennedy,David E. Hill,Robert T. Abraham +5 more
TL;DR: Wortmannin is identified as an inhibitor of ATM activity and it is suggested that ATM and DNA-PK are relevant targets for the radiosensitizing effect of this drug in cancer cells.